The role of CD8+T cells in nonalcoholic steatohepatitis
- VernacularTitle:CD8+T淋巴细胞在非酒精性脂肪性肝炎中的作用
- Author:
Yiming ZHAO
1
;
Kaiyang LI
;
Mei YANG
;
Qi ZHAO
Author Information
- Keywords: Non-alcoholic Fatty Liver Disease; CD8-Positive T-Lymphocytes; Adipose Tissue; Inflammation; Epigenetics
- From: Journal of Clinical Hepatology 2024;40(10):2087-2091
- CountryChina
- Language:Chinese
- Abstract: Nonalcoholic steatohepatitis(NASH)is a liver disease closely associated with metabolic syndrome,and its pathogenesis includes insulin resistance,lipid metabolism disorders,and inflammatory response.This article briefly describes how CD8+T cells exert a cytotoxic effect through the three pathways of the Fas-Fas ligand signaling pathway,the release of perforin and granzymes,and the secretion of tumor necrosis factor-α and other cytokines,and these mechanisms allow CD8+T cells to specifically kill virus-infected cells and tumor target cells,thereby participating in immune regulation.At the same time,this article summarizes that CD8+T cells promote the recruitment of macrophages cooperate with natural killer T cells to participate in the development of adipose tissue inflammation,and lead to liver injury through automatic attack and epigenetic mechanisms,finally promoting the pathogenesis of NASH.It is concluded that CD8+T cells may become a new therapeutic target for NASH,and in-depth research on the specific mechanism of CD8+T cells affecting the pathogenesis in NASH in the future may help to further guide clinical treatment.
