Research advances in the pathogenesis of metabolic associated fatty liver disease
10.12449/JCH241005
- VernacularTitle:代谢相关脂肪性肝病的发病机制与中医病机
- Author:
Shukun YAO
1
;
Jing LIU
;
Tianhui ZHOU
Author Information
1. 中日友好医院消化科,北京 100029
- Keywords:
Non-alcoholic Fatty Liver Disease;
Lipid Metabolism;
Etiological Factors and Pathogenesis(TCM)
- From:
Journal of Clinical Hepatology
2024;40(10):1954-1958
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic associated fatty liver disease(MAFLD)is currently the most common liver disease around the world.MAFLD may easily progress to the adverse outcomes such as hepatitis,liver fibrosis,and liver cirrhosis,and it is often accompanied by comorbidities such as diabetes,hypertension,hyperlipidemia,hyperuricemia,and cardiovascular and cerebrovascular diseases.Etiological treatment is the cornerstone of MAFLD treatment,and due to the complexity and adverse outcome of MAFLD,it is of great significance to explore the pathogenesis of MAFLD and develop effective prevention and treatment regimens and drugs.This article reviews the pathogenesis of MAFLD from the aspects of genetic factors,improper diet and oxidative stress,spleen-stomach damp-heat and insulin resistance,damp-heat and pathogenic Qi,organic acid metabolism,and intestinal microecology.
