Advances in Research on Lactate Metabolism Disorders and Their Effect on Immu-notherapy in Lung Adenocarcinoma
10.3971/j.issn.1000-8578.2024.24.0334
- VernacularTitle:肺腺癌中乳酸代谢紊乱及其对免疫治疗影响的研究进展
- Author:
Liangjian ZHENG
1
;
Gangfeng ZHU
;
Junyan LI
;
Jie CHE
;
Cixiang CHEN
;
Yi XIANG
;
Huaqiu SHI
Author Information
1. 341000 赣州,赣南医科大学第一临床医学院
- Keywords:
Lung adenocarcinoma;
Lactate metabolism;
Immunotherapy;
Tumor microenvironment;
Immune escape
- From:
Cancer Research on Prevention and Treatment
2024;51(10):883-886
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies have identified that metabolic reprogramming in lung adenocarcinoma cells,particularly lactate metabolism disorders,plays a crucial role in tumor development and immune therapy response.The accumulation of lactic acid not only provides energy support for the proliferation of tumor cells but also affects the function of immune cells by changing the tumor microenvironment,thereby promoting immune escape.Immunotherapy,especially the application of immune checkpoint inhibitors,has become an important strategy for treating lung adenocarcinoma.However,lactate metabolism disorders might affect the efficacy of immunotherapy,leading to resistance in some patients.Therefore,a thorough understanding of the mechanisms of lactic acid metabolism in lung adenocarcinoma and its impact on the response to immu-notherapy is essential for developing new therapeutic strategies and improving the efficacy of immunoth-erapy.This review summarizes the role of lactate metabolism disorders in the development and immun-otherapy of lung adenocarcinoma,discusses the potential role of lactic acid metabolism-related genes and pathways in lung adenocarcinoma,and explores the progress in therapeutic strategies targeting lactic acid metabolism regulation.This work aims to provide new insights for the treatment of lung adenocarcinoma.
