Relationship Between High-Density Lipoprotein Cholesterol and Colorectal Cancer—A Mendelian Randomization Study
10.3971/j.issn.1000-8578.2024.24.0153
- VernacularTitle:高密度脂蛋白胆固醇与结直肠癌关系的孟德尔随机化研究
- Author:
Chendong YUAN
1
,
2
;
Xufeng SHU
1
,
2
;
Xiaoqiang WANG
1
,
2
;
Zhigang JIE
1
,
2
Author Information
1. Department of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China
2. Medical Innovation Center, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China.
- Publication Type:CLINICALRESEARCH
- Keywords:
High-density lipoprotein cholesterol;
Colorectal cancer;
Mendelian randomization
- From:
Cancer Research on Prevention and Treatment
2024;51(10):847-851
- CountryChina
- Language:Chinese
-
Abstract:
Objective To elucidate the causal relationship between high-density lipoprotein cholesterol (HDL-C) and colorectal cancer (CRC) through Mendelian randomization. Methods Mendelian randomization analysis was conducted using genetic instrumental variables selected from a genome-wide association study dataset. The main methods included inverse variance weighted, MR-Egger, weighted median, simple mode, and weighted mode method; among which, inverse variance weighted method served as the primary analytical approach. Sensitivity analyses were performed to verify the robustness of results. Results A total of 41 genetic instrumental variables associated with HDL-C were identified. Inverse variance weighted method (OR=0.84, 95%CI: 0.73-0.96, P=0.01) and weighted median method (OR=0.82, 95%CI: 0.67-0.99, P=0.04) indicated a negative correlation between genetically-determined HDL-C and CRC risk. Sensitivity analyses confirmed the absence of heterogeneity and horizontal pleiotropy (P>0.05). Conclusion A causal relationship exists between HDL-C and CRC risk, with rs1077834 as a potential key determinant in the influence of HDL-C on CRC risk.
