Research Progress on Pathogenesis of Ankylosing Spondylitis and Intervention of Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20240536
- VernacularTitle:强直性脊柱炎的发病机制及中药干预研究进展
- Author:
Zhendong WANG
1
;
Juanjuan YANG
1
;
Haolin LI
1
;
Dongsheng LU
1
;
Qian BAI
1
;
Weigang CHENG
1
;
Ping CHEN
2
;
Haidong WANG
2
Author Information
1. Gansu University of Traditional Chinese Medicine （TCM），Lanzhou 730000，China
2. Gansu Provincial Hospital of TCM Rheumatism Osteopathy Center，Lanzhou 730050，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
ankylosing spondylitis;
inflammatory reaction;
bone destruction;
heterotopic ossification
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(22):289-298
- CountryChina
- Language:Chinese
-
Abstract:
Ankylosing spondylitis （AS） is an inflammatory autoimmune disease with chronic low back pain as the main clinical manifestation， which mainly affects the axial joints， peripheral joints and various organs. In severe cases， the spine is stiff or deformed， which affects the quality of life and health of patients. The pathogenic factors of AS are complex， which are related to heredity， immunity and intestinal flora. The pathogenesis of AS is not clear yet. Among them， inflammatory reaction， bone destruction and heterotopic ossification are the main pathological features of AS， which play an important role in the disease process of AS. Traditional Chinese medicine has multi-target， multi-channel and multi-component pharmacological effects， which can prevent and treat AS by anti-inflammation， inhibiting bone destruction and preventing heterotopic ossification， and the clinical effect is remarkable， but there is no relevant literature report. Therefore， this review expounds the relationship between inflammatory reaction， bone destruction and heterotopic ossification and the occurrence and development of AS， and summarizes the latest research reports of traditional Chinese medicine in treating AS from anti-inflammatory， inhibiting bone destruction and preventing heterotopic ossification， aiming at providing reference and new ideas and directions for further research on the prevention and treatment of AS by traditional Chinese medicine.
