Glaucocalyxin A： A Review
10.13422/j.cnki.syfjx.20240638
- VernacularTitle:蓝萼甲素的现代研究进展
- Author:
Yuqian LU
1
;
Qingchao TU
2
;
Hailu YAO
2
;
Jigang WANG
1
;
Fei XIA
2
Author Information
1. School of Public Health， Guangxi Medical University， Nanning 530021， China
2. Artemisinin Research Center， China Academy of Chinese Medical Sciences， Beijing 100700， China
- Publication Type:Review
- Keywords:
glaucocalyxin A;
total synthesis;
pharmacological activity;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(22):249-258
- CountryChina
- Language:Chinese
-
Abstract:
Glaucocalyxin A （GLA） is a natural diterpenoid extracted from Isodon amethystoides belonging to Labiatae. Modern pharmacological research has shown that GLA has anti-inflammatory， anti-tumor， anti-fibrotic， osteoporosis-ameliorating， and cardiovascular system-protecting activities and good biosafety. However， the low content in plants， poor solubility， high metabolic rate， and low bioavailability limit the application of GLA. To address these issues， researchers have studied the total synthesis， structural modification， and nanomedicine development of GLA. By reviewing the available studies about GLA in the past five years， we summarize the research progress in the total synthesis， pharmacological activities and mechanisms， and in vivo metabolic transformation， aiming to provide a theoretical basis for clarifying the specific mechanisms underlying the pharmacological activities of GLA and for further research， development， and clinical applications of GLA.
