Methodological Consideration on Combination Model of TCM Clinical Practice Guidelines and Real-world Study
10.13422/j.cnki.syfjx.20240824
- VernacularTitle:中医临床实践指南联合真实世界研究模式的方法学思考
- Author:
Guozhen ZHAO
1
;
Huizhen LI
1
;
Ning LIANG
1
;
Haili ZHANG
1
;
Bin LIU
1
;
Qianzi CHE
1
;
Feng ZHOU
2
;
He LI
2
;
Xiaowen CHEN
2
;
Long YE
2
;
Jiahao LIN
1
;
Xingyu ZONG
1
;
Dingyi WANG
1
;
Nannan SHI
1
;
Yanping WANG
1
Author Information
1. Institute of Basic Research in Clinical Medicine， China Academy of Chinese Medical Sciences， Beijing 100700， China
2. School of Clinical Medicine， Beijing University of Chinese Medicine， Beijing 100029， China
- Publication Type:Journal Article
- Keywords:
guidelines;
real-world study;
evidence content;
traditional Chinese medicine;
real-world evidence
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(22):87-93
- CountryChina
- Language:Chinese
-
Abstract:
The clinical practice guidelines of traditional Chinese medicine （TCM） have problems such as limited clinical application and unclear implementation effects， which may be related to the lack of clinical practice evidence. To provide reliable and precise evidence for clinical practice， this article proposes a model of combining TCM guidelines with real-world study， which includes 4 steps. Firstly， during the implementation process of the guidelines， a high-quality research database is established. Secondly， the recommendations in the guidelines are evaluated based on the established database in multiple dimensions， including applicability， effectiveness， safety， and cost-effectiveness， and thus their effectiveness in practical applications can be determined. Thirdly， based on the established database， core prescriptions are identified， and the targeted populations and medication plans are determined. That is， the best treatment regimen is established based on the analysis of abundant clinical data regarding the effects of different medication frequencies， dosages， and duration on efficacy. Fourthly， the guidelines are updated according to the real-world evidence. The research based on this model can provide real-world evidence for ancient and empirical prescriptions， improving their application in clinical practice. Moreover， this model can reduce research costs and improve research efficiency. When applying this model， researchers need to pay attention to the quality of real-world evidence， ensuring that it can truly reflect the situation in clinical practice. In addition， importance should be attached to the clinical application of guideline recommendations， ensuring that doctors can conduct standardized diagnosis and treatment according to the guidelines. Finally， full-process participation of multidisciplinary experts is encouraged to ensure the comprehensiveness and scientificity of the study. In conclusion， the application of this model will contribute to the development of TCM guidelines responsive to the needs of clinical practice and achieve the goal of promoting the homogenization of TCM clinical diagnosis and treatment.
