The efficacy of standardized allergen subcutaneous specific immunotherapy in children with monosensitized versus polysensitized allergic asthma
10.19405/j.cnki.issn1000-1492.2023.07.023
- Author:
Jinyu Yang
1
,
2
,
3
;
Shenggang Ding
1
,
2
,
3
;
Suli Zhang
1
,
2
,
3
;
Yulin Zhu
1
,
2
,
3
;
Junli Ding
1
,
2
,
3
;
Shaohu Huo
1
,
2
,
3
;
Yanfeng Zou
4
Author Information
1. Dept of Pediatrics , The First Afiliated Hospital of Anhui Medical University,Hefei 230022
2. Beijing Children &prime
3. s Hospital , Capital Medical University, China National Clinical Research Center of Respiratory Diseases , Beijing 100045
4. School of Public Health , Anhui Medical University, Hefei 230032)
- Publication Type:Journal Article
- Keywords:
standardized allergen subcutaneous specific immunotherapy;
dust mite;
childhood asthma;
monosen⁃ sitized;
polysensitized
- From:
Acta Universitatis Medicinalis Anhui
2023;58(7):1200-1204
- CountryChina
- Language:Chinese
-
Abstract:
Objective : To investigate the efficacy of standardized allergen subcutaneous immunotherapy (SCIT) in
children with asthma sensitized to single dust mite allergens versus multiple allergens and to assess the safety of SCIT.
Methods :62 children with confirmed allergic asthma who received standardized allergen SCIT were retro⁃
spectively analyzed and divided into the monosensitized group (dust mite results≥ + + + ) and the polysensitized group (dust mite results ≥ + + + combined with other positive allergens) according to the results of skin pricktest , we observed the changes of pulmonary function , medication score and visual analog scale (VAS) scores , children asthma control test (C - ACT) scores , asthma control questionnaire (ACQ) scores before and after treatment in both groupsand compared the efficacy of the two groups. The incidence of local and systemic adverse effects was recorded during treatment in all children to assess the safety of SCIT.
Results : Standardized allergen SCIT treatmentimproved lung function parameters , medication scores and VAS scores , C ⁃ACT scores , ACQ scores in both the monosensitized and polysensitized groups , with statistically significant differences before and after treatment (P < 0. 05) . In comparison between the two groups , lung function parameters [forced expiratory flow at 50% vital capacity(FEF50% ) , maximum midexpiratory flow(MMEF)] , medication scores , C ⁃ACT scores and ACQ scores
improved significantly in the monosensitized group compared with the polysensitized group after treatment ( P <0. 001) . 62 patients received a total of 2 606 injections during the treatment of SCIT , 6 children had a total of 10 local adverse reactions and 3 children had 3 mild to moderate systemic adverse reactions , with an incidence of 0. 38% for local adverse reactions and 0. 12% for systemic adverse reactions.
Conclusion :The children with asthma in both the monosensitized group and polysensitized group achieved significant and safe clinical outcomes under standardized allergen SCIT. The children in the monosensitized group had more obvious clinical effects than the polysensitized group under standardized allergen SCIT.
- Full text:2024101510594204811标准化变应原皮下特异性免疫...重过敏性哮喘儿童的疗效对比_杨瑾禹.pdf
