Analysis of clinical characteristics of 105 cases of cholestatic drug-induced liver injury
https://kns.cnki.net/kcms2/article/abstract?v=WnCf0VAm38ojLE13511aC1HaSdVOpvVmZZdLb2ZeE0vOwoJxYQd-xiy_rCK3yQ6NkBk2SEfGzfxQ9jXS3DQDh4CqVRXgjapFGXTTYkoazffGn_tSj8uLwISX-2sOTePkF86nEmuESvRFEg_YN4JYzztnfoAmWSUF9d9qNisUNb0EYLl48dixye1Ah0K0J6dq&uniplatform=NZKPT&language=CHS
- Author:
Qiannan Chen
1
;
Yan Xu
1
;
Xiaochang Liu
1
;
Qiao Mei
1
;
Weiping Weiping
1
;
Jianming Xu
1
Author Information
1. Dept of Gastroenterology，The First Affiliated Hospital of Anhui Medical University，Hefei 230022
- Publication Type:Journal Article
- From:
Acta Universitatis Medicinalis Anhui
2023;58(6):1036-1040
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore the general information，clinical features，imaging findings and outcome of pa- tients with drug-induced cholestatic．
Methods : The clinical data of patients diagnosed as cholestatic drug-induced liver injury in recent 5 years were analyzed retrospectively，and followed up for at least 6 months.
Results : There were 105 patients with drug-induced cholestatic liver injury in the hospital，the median age was 55 years old (54. 3% male) ，most of them had no specific clinical symptoms ; there were nearly 80 kinds of drugs involved，the top three were traditional Chinese medicine (34. 3% ) ，antineoplastic drugs (22. 9% ) and antibiotics ( 10. 5% ) . Among the 49 patients with magnetic resonance cholangiopancreatography ( MRCP) ，7 ( 14. 3% ) had sclerosing cholangitis-like changes ; most of the patients were combined with multiple liver-protecting and enzyme-lowering drugs ; there were 53 cured (50. 5% ) ，41 improved (39. 0% ) ，7 uncured (6. 7% ) ，and 4 died (3. 8% ) among 105 patients，and the total effective rate was 89. 5%．
Conclusion : Drug-induced cholestatic liver injury mainly oc- curs in elderly patients，involving many kinds of drugs，mainly traditional Chinese medicine．Drugs can also cause changes similar to sclerosing cholangitis，so drug-induced liver injury (DILI) should be used as one of the differen- tial diagnosis of cholestasis and abnormal cholangiography．Liver disease and the number of drugs have no effect on the prognosis of the patients，while low Roussel Uclaf causality assessment method (RUCAM) score and hemoglobin count，short hospitalization time and high white blood cell count are poor prognostic factors.
- Full text:2024101510103502232105例药物性胆汁淤积型肝损伤患者临床特征分析_陈茜楠.pdf
