Role of triglyceride glycemic body mass index in predicting recurrent pregnancy loss
10.19405/j.cnki.issn1000-1492.2023.06.024
- Author:
Yinshuang Xue
1
,
2
,
3
;
Yingming He
1
,
2
,
3
;
Yue Huang
1
,
2
,
3
;
Zhenran Liu
1
,
2
,
3
;
Pin Zhang
1
,
2
,
3
;
Huifen Xiang
1
,
2
,
3
Author Information
1. Reproductive Medicine Center，Dept of Obstetrics and Gynecology，The First Affiliated Hospital of Anhui Medical University，Hefei 230022
2. Anhui Province Key Laboratory of Reproductive Health and Genetics，Anhui Medical University，Hefei 230022
3. Anhui Provincial Engineering Technology Research Center for Biopreservation and Artificial Organs，Hefei 230051
- Publication Type:Journal Article
- Keywords:
recurrent pregnancy loss;
insulin resistance;
TyG index;
TyG-BMI index;
HOMA-IR
- From:
Acta Universitatis Medicinalis Anhui
2023;58(6):1020-1024
- CountryChina
- Language:Chinese
-
Abstract:
Objective : To analyze the metabolism of blood glucose，blood lipid and insulin in patients with recur- rent pregnancy loss (RPL) ，and to compare the predictive efficacy of triglyceride glycemic index (TyG) ，triglycer- ide glycemic body mass index (TyG-BMI) and homeostatic model assessment of insulin resistance( HOMA-IR) for RPL．
Methods :A total of 573 patients with RPL were selected as the RPL group，and 652 women who received as- sisted reproductive technology for male infertility were selected as the control group．The general data of the two groups were retrospectively analyzed．The levels of body mass index(BMI) ，fasting blood glucose (FPG) ，fasting triglyceride (FTG) ，fasting insulin ( FINS) ，TyG index，TyG-BMI index and HOMA-IR were compared between the two groups．Spearman correlation analysis was used to verify the correlation between TyG index，TyG-BMI in- dex and HOMA-IR. Receiver operating characteristic (ROC) curve was used to evaluate the predictive efficacy of TyG index，TyG-BMI index and HOMA-IR for RPL occurrence，and the optimal predictive cut-off point was calculated.
Results :The BMI，FPG，FTG，TyG index，TyG-BMI index and HOMA-IR in the RPL group were significantly higher than those in the control group (P＜0. 05) ．TyG index and TyG-BMI index were positively correlated with HOMA-IR , and the correlation coefficients were 0. 442 and 0. 505，respectively (P＜0. 001) . ROC curve a- nalysis showed that the area under the curve of TyG-BMI index predicting RPL was 0. 579 (95% CI : 0. 551 - 0. 607，P＜0. 001) ，which was greater than that of TyG index of 0. 557 (95% CI : 0. 529－0. 585，P＜0. 001) and HOMA-IR of 0. 535 (95% CI : 0. 507 －0. 563，P ＜0. 05) ，among which the difference between TyG-BMI index and HOMA-IR index area under the curve was statistically significant (P ＜0. 05 ) ．The optimal cut-off points of TyG-BMI index ，TyG index and HOMA-IR for predicting RPL were 172. 3 ( sensitivity 75. 7% ，specificity 37. 06% ) ，8. 32 ( sensitivity 59. 44% ， specificity 51. 61% ) and 3. 58 ( sensitivity 25. 87% ， specificity 81. 62% ) ，respectively．
Conclusion : The incidence of overweight，abnormal blood glucose，lipid and insulin me- tabolism in RPL patients is higher than that in normal women．TyG index and TyG-BMI index can be used as indi- cators of insulin metabolic status in RPL population besides HOMA-IR , and TyG-BMI index has a higher efficacy in predicting the occurrence of RPL compared to HOMA-IR.
- Full text:2024101509533948668甘油三酯血糖体质指数在反复妊娠丢失预测中的作用_薛吟霜.pdf
