Reexploration of glucose metabolism in childhood obesity
10.19405/j.cnki.issn1000-1492.2023.06.023
- Author:
Wu Peng
1
;
Deyun Liu
1
;
Liqi Yang
1
;
yue Yu
1
Author Information
1. Dept of Pediatrics，The Second Affiliated Hospital of Anhui Medical University，Hefei 230601
- Publication Type:Journal Article
- Keywords:
obese children;
prediabetes;
impaired fasting blood glucose;
impaired glucose tolerance;
insulin re- sistance
- From:
Acta Universitatis Medicinalis Anhui
2023;58(6):1016-1020
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To analyze the status of glucose metabolism in obese children．
Methods : 266 cases of obese children were included in the study，fasting plasma glucose ( FPG) ，fasting insulin ( FINS) ，glycosylated hemoglobin ( HbA1c) were measured ，Oral glucose tolerance test ( OGTT) and insulin release test ( IRT) were carried out，insulin resistance index ( HOMA-IR) ，quantified insulin sensitivity index ( QUICKI) and peak insu- lin /fasting insulin (Ip / I0 ) were calculated．Two hundred non-obese healthy children were used as control group， and glucose metabolism indexes were compared between the two groups． Glucose metabolism indexes and the incidence of insulin resistance (IR) were compared in children with different degrees of obesity ．Prediabetes risk factors and body mass index(BMI) correlation were analyzed in obese children.
Results :The proportion of predia- betes and type 2 diabetes mellitus in obese children was 18. 0% (48 /266) ．FINS，HOMA-IR and HbA1c in obesi- ty group were higher than those in the control group，but QUICKI was lower than that in the control group (P < 0. 05) ．There was no significant difference in FPG between the two groups (P = 0. 423) ．FINS and HOMA-IR of severe obesity group were higher than those of mild to moderate obesity group，Ip / I0 was lower than that of mild to moderate obesity group (P＜0. 05) ，and there was no significant difference in FPG，QUICKI，HbA1c and 2hPG of severe obesity group．There was no significant difference in IR incidence between mild to moderate obesity group and severe obesity group (P = 0. 163) ．Logistic regression indicated that BMI and acanthosis nigricans was great influential on prediabetes with no statistical significance(P＞0. 05) ．Correlation analysis showed that BMI had no correlation with FPG (P = 0. 160) ，but was positively correlated with FINS，HOMA-IR , 2hPG and HbA1c (P < 0. 05) ，and negatively correlated with QUICKI and Ip / I0 (P＜0. 05) ．
Conclusion :Abnormal glucose metabolism is available in nearly 20% of obese children．The prevalence of insulin resistance in obese children is not affected by the degree of obesity.
- Full text:2024101509492559780儿童肥胖症糖代谢状态的再探讨_彭武.pdf
