Research progress on the potential mechanisms of Porphyromonas gingivalis in promoting Alzheimer's dis-ease
10.12016/j.issn.2096-1456.202440197
- VernacularTitle:牙龈卟啉单胞菌促进阿尔茨海默病的机制研究进展
- Author:
Yujie WANG
1
;
Xian PENG
;
Ga LIAO
;
Xuedong ZHOU
Author Information
1. 口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心 四川大学华西口腔医院 牙体牙髓病科,四川 成都(610041)
- Keywords:
Porphyromonas gingivalis;
Alzheimer's disease;
gingipains;
blood-brain barrier;
periodontitis;
neurodegenerative diseases;
amyloid beta-protein
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2024;32(10):797-804
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD),a common neurodegenerative disease,has been linked to periodontitis,espe-cially Porphyromonas gingivalis(P.gingivalis)infection.This review summarizes the potential mechanisms and path-ways through which P.gingivalis and its virulence factors are involved in AD pathogenesis,aiming to provide the scien-tific basis for the development of novel prevention and treatment strategies for AD.P.gingivalis can promote AD by ex-acerbating neuroinflammation,facilitating amyloid beta and Tau deposition,and disrupting the blood-brain barrier.Gin-gipains,secreted by P.gingivalis,serve as core effector molecules by increasing the blood-brain barrier permeability.The association between P.gingivalis and its effectors and AD pathology has been validated by metagenomic analysis and sample detection,indicating that P.gingivalis may be an environmental susceptibility factor or modifiable risk fac-tor for AD.However,the precise mechanisms by which P.gingivalis influences AD,and its interactions with other po-tential AD-related factors,remain unclear.Moreover,further research needs to be conducted on the therapeutic potential of P.gingvalis intervention in improving AD.
