Expression of TROP2 protein in salivary adenoid cystic carcinoma and its correlation with the prognosis of pa-tients with salivary adenoid cystic carcinoma
10.12016/j.issn.2096-1456.202440159
- VernacularTitle:TROP2蛋白在涎腺腺样囊性癌中的表达及与患者预后的关系
- Author:
Bo DONG
1
;
Manman YAO
;
Hongyue SHANG
;
Kaicheng YANG
;
Tiejun LIU
Author Information
1. 河北医科大学第四医院口腔科,河北 石家庄(050011)
- Keywords:
salivary adenoid cystic carcinoma;
prognosis;
immunohistochemistry;
trophoblast cell-surface anti-gens 2;
biomarker;
clinical staging;
clinicopathological features;
disease-free survival;
survival analysis
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2024;32(10):765-771
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of trophoblast cell-surface antigen 2(TROP2)in salivary ade-noid cystic carcinoma(SACC)in order to analyze its relationship with TROP2 expression and clinicopathological features,as well as to clarify the correlation between TROP2 expression and the prognosis of patients with SACC.Methods With approval from the ethics committee,the expression of TROP2 in 85 SACC and paracancer tissue sam-ples was detected by using the immunohistochemical method,and the relationship between TROP2 expression and clini-copathological characteristics was analyzed.The Kaplan-Meier method was used to analyze the relationship between TROP2 protein expression and 5-year disease-free survival(DFS)in 40 patients with SACC.Furthermore,the logistic re-gression model was used to analyze the prognostic factors of patients with SACC.Results The low or no expression rate of TROP2 in SACC tissues was significantly higher than that in paracancer tissues(P＜0.001).Low or no expres-sion of TROP2 was significantly positively correlated with tumor growth and clinical staging in patients with SACC(P＜0.05).Kaplan-Meier survival analysis showed that the DFS of patients with SACC with low or no expression of TROP2 protein was significantly lower than those of patients with high expression of TROP2 protein(P＜0.05),and the progno-sis was poor.The logistic regression model showed that low or no expression of TROP2 protein(OR=5.37;95%CI:1.03-28.08;P=0.046)and Ⅲ-Ⅳ clinical staging(OR=6.89;95%CI:1.37～34.77;P=0.019)were risk factors affect-ing the prognosis of patients with SACC.Conclusion Low or no expression of TROP2 protein in SACC tissues leads to poor prognosis of patients and is positively correlated with tumor growth and clinical staging.In addition,low or no ex-pression of TROP2 can be used as an independent prognostic risk factor for poor prognosis in patients with SACC,and TROP2 is a marker of poor prognosis in patients with SACC.
