Advances in effect mechanism research of traditional Chinese medicine on comorbid depressive symptoms in chronic pain
- VernacularTitle:中医药对慢性疼痛-抑郁共病的作用机制研究进展
- Author:
Guanghua LIU
1
;
Dongliang SHI
1
,
2
;
Wen FU
3
;
Zihua WANG
3
;
Jiakang CUI
2
Author Information
1. College of Orthopedics and Traumatology，Henan University of Chinese Medicine，Zhengzhou 450046，China
2. Bone Injury Diagnosis and Treatment Center，the Second Affiliated Hospital of Henan University of Chinese Medicine/Henan Province Hospital of TCM，Zhengzhou 450002，China
3. Dept. of Rheumatology and Immunology，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450014，China
- Publication Type:Journal Article
- Keywords:
comorbid depressive symptoms in chronic pain;
traditional Chinese medicine monomer;
traditional Chinese
- From:
China Pharmacy
2024;35(19):2438-2443
- CountryChina
- Language:Chinese
-
Abstract:
Chronic pain refers to pain that persists or recurs for more than 3 months and has a high comorbidity rate with emotions such as depression and anxiety. The complex pathogenesis of comorbid depressive symptoms in chronic pain poses great challenges to clinical diagnosis and treatment. This article reviews the research progress on the effect mechanism on the comorbid depressive symptoms in chronic pain by traditional Chinese medicine monomers， compound formulas， and acupuncture therapy in recent years. It is found that traditional Chinese medicine monomers （flavonoids， phenols， terpenes， coumarins， alkaloids）， traditional Chinese medicine formulas （Aconitum carmichaeli decoction， Chaihu guizhi decoction， etc.）， and acupuncture therapy （acupuncture at acupoints such as Baihui， Yintang， Hegu， and Taichong） can effectively improve comorbid depressive symptoms in chronic pain by regulating the levels of neurotransmitters， brain-derived neurotrophic factors and inflammatory factors， and the activity of glial cells in the central nervous system.
