Effects of active ingredients of traditional Chinese medicine in the prevention and treatment of senile macular degeneration and the research progress of its ocular new drug delivery preparations
- VernacularTitle:中药活性成分防治老年性黄斑变性的作用及其新型眼部递送制剂研究进展
- Author:
Yadi ZHU
1
;
Wei LI
2
;
Shuyao LI
3
;
Hanmei LI
4
;
Liang ZOU
4
Author Information
1. College of Pharmacy，Chengdu University，Chengdu 610106，China
2. College of Basic Medical Sciences，Chengdu University，Chengdu 610106，China
3. College of Pharmacy，Chengdu University of Traditional Chinese Medicine，Chengdu 611137，China
4. College of Food and Biological Engineering，Chengdu University，Chengdu 610106，China
- Publication Type:Journal Article
- Keywords:
senile macular degeneration;
active ingredients of traditional Chinese medicine;
oxidative stress;
inflammation
- From:
China Pharmacy
2024;35(19):2432-2437
- CountryChina
- Language:Chinese
-
Abstract:
Senile macular degeneration（SMD） is a degenerative disease of the macular region of the eye that causes visual impairment in older people worldwide. It is the focus and difficulty of the treatment of ophthalmic diseases at home and abroad. This paper reviewed traditional Chinese medicine （TCM） active ingredients for the treatment and prevention of SMD， and its new ocular delivery preparations. Studies have shown that many active ingredients of TCM can inhibit the progression of SMD through various ways such as anti-oxidation， solid lipid nanoparticles， microemulsions/nanoemulsions， in-situ gel， etc. However， due to the low solubility， chemical instability and difficulty in overcoming the eye barrier of most TCM active ingredients， their clinical application in the treatment of SMD is seriously hindered. New preparations， such as liposomes， solid lipid nanoparticles， microemulsion/nanoemulsion， in situ gels， have good application prospects in ocular drug delivery.
