Research progress on the mechanism of saponin compounds intervening in colorectal cancer by regulating gut microbiota
- VernacularTitle:皂苷类化合物通过调节肠道菌群干预结直肠癌的机制研究进展
- Author:
Haoyu ZHAI
1
;
Xue CHEN
1
;
Bingwei YANG
1
;
Chenglei WANG
2
;
Weidong LI
1
Author Information
1. Dept. of Scientific Research Management，Guang’anmen Hospital，China Academy of Chinese Medical Sciences，Beijing 100053，China
2. School of Graduate，Shaanxi University of Chinese Medicine，Shaanxi Xianyang 712046，China
- Publication Type:Journal Article
- Keywords:
saponin;
gut microbiota;
colorectal cancer;
Akkermansia muciniphila;
mechanism
- From:
China Pharmacy
2024;35(19):2426-2431
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer is one of the leading causes of cancer-related deaths worldwide. Specific gut microbiota can identify high-risk populations for colorectal cancer and may slow disease progression by regulating apoptosis， producing intestinal metabolites， and enhancing chemotherapy efficacy （reducing side effects and improving chemotherapy resistance）. Saponins represented by ginsenoside K are found widely in traditional medicines such as Panax ginseng and Panax notoginseng. After metabolized by gut microbiota， they play a role in preventing and treating colorectal cancer by modulating chronic inflammation， adjusting the composition of gut microbiota， generating microbial metabolites， and participating in immune regulation.
