Association between umbilical artery ultrasound parameters and birth outcomes in gestational diabetes mellitus
10.19405/j.cnki.issn1000-1492.2023.07.020
- Author:
Ying Pan
1
;
Li Zhou
1
;
Lianjie Dou
1
;
Jijun Gu
1
;
Dan Huang
1
;
Zhaohui Huang
1
;
Anhui Zhang
2
;
Hong Tao
2
;
Li Zhang
2
;
Jiahu Hao
3
,
4
Author Information
1. Dept of Maternal , Child and Adolescent Health ,School of Public Health ,Anhui Medical University,Hefei 230032
2. Dept of Obstetrics and Gynecology, Wuhu Maternal and Child Health Care Hospital , Wuhu 241000
3. Dept of Maternal , Child and Adolescent Health ,School of Public Health ,Anhui Medical University,Hefei 230032
4. Key Laboratory ofPopulation Health Across Life Cycle (Anhui Medical University) , Hefei 230032
- Publication Type:Journal Article
- Keywords:
gestational diabetes mellitus;
umbilical artery blood flow parameters;
placenta
- From:
Acta Universitatis Medicinalis Anhui
2023;58(7):1184-1188
- CountryChina
- Language:Chinese
-
Abstract:
Objective : To investigate the effects of gestational diabetes mellitus (GDM) on birth outcome and umbilical artery (UA) blood flow parameters in the third trimester, and to analyze the role of UA blood flow parameters in GDM and birth outcome.
Methods :Based on the birth cohort from Wuhu , Anhui , China , 189 pregnant women with GDM were collected as the case group. The non⁃GDM pregnant women were matched 1 ∶ 1 according to age and pre⁃pregnancy body mass index , and 189 normal pregnant women were selected as the control group. Pregnant women with GDM were divided into poorly controlled group and well controlled group according to fasting blood
glucose in the third trimester. The UA blood flow parameters and fetal birth outcomes in the third trimester were tracked.
Results :Compared with the control group , UA parameters in poorly controlled and well controlled groups
significantly increased (F = 6. 63 , P < 0. 05 ; F = 4. 43 , P < 0. 05 ; F = 5. 57 , P < 0. 05) . Poor glycemic control of GDM was associated with increased birth weight and risk of larger than gestational age. The multi⁃factor linear regression model showed that the Z score of the peak systolic velocity/end diastolic velocity (S/D) in the poorly controlled group was negatively correlated with birth weight (β = - 209. 78 , 95% CI: - 301. 48 - 118. 07) . S/D index Z score mediated the relationship between poor blood glucose control and birth weight. The intermediate effect value was - 58. 41 (95% CI: - 106. 40 ~ - 19. 65) , accounting for 25. 98% of the total effect.
Conclusion : Poor glycemic control in GDM is a risk factor for fetal weight gain , and UA function plays a partial mediating role in influencing neonatal birth weight. GDM pregnant women should strictly control blood glucose level to better protect maternal and infant health.
- Full text:2024101016591199549妊娠期糖尿病与出生结局的关...：脐动脉血流参数的中介作用_潘颖.pdf
