Association between gut microbiota and polycystic ovary syndrome: a Mendelian randomization study
10.19485/j.cnki.issn2096-5087.2024.09.015
- Author:
CHEN Ying
;
LIU Ke
;
LIU Bin
;
SUN Xiaohui
;
HE Zhixing
;
MAO Yingying
;
YE Ding
- Publication Type:Journal Article
- Keywords:
polycystic ovary syndrome;
gut microbiota;
Streptococcus;
Actinomyces;
Mendelian randomization
- From:
Journal of Preventive Medicine
2024;36(9):801-805
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the causal relationship between gut microbiota and polycystic ovary syndrome (PCOS) using a Mendelian randomization (MR) study, so as to provide insights into the pathogenesis of PCOS and the formulation of prevention and treatment strategies.
Methods:The genetic data on gut microbiota was derived from a meta-analysis of genome-wide association studies (GWAS) involving 18 340 participants. The genetic data on PCOS was sourced from two GWAS meta-analyses in European populations, serving as the discovery set and the validation set, respectively. A two-sample MR analysis was conducted using the discovery set, with the inverse variance weighted (IVW) method as the primary approach. Sensitivity analyses employed the weighted median method, MR-Egger regression, and the MR-PRESSO test. The validation set was utilized for verification, and a meta-analysis was performed to combine the results from the two datasets.
Results:Forward MR analysis results showed that nine types of gut microbiota were statistically associated with PCOS (all P<0.05). Specifically, the association of family Streptococcaceae (OR=1.442, 95%CI: 1.097-1.895), genus Actinomyces (OR=1.359, 95%CI: 1.036-1.784), genus Ruminococcaceae UCG 011 (OR=0.755, 95%CI: 0.619-0.921), genus Sellimonas (OR=0.766, 95%CI: 0.657-0.893) and genus Streptococcus with PCOS (OR=1.496, 95%CI: 1.136-1.972) remained consistent in the sensitivity analysis. Reverse MR analysis showed no evidence for the causal association between PCOS and the aforementioned five types of gut microbiota (all P>0.05). The MR analysis results of the validation set showed that there was no statistical association between the aforementioned five types of gut microbiota and PCOS (all P>0.05). However, the associations remained significant for genus Actinomyces (OR=1.226,95%CI：1.010-1.503) and genus Streptococcus (OR=1.266,95%CI：1.042-1.452) in the meta-analysis (both P<0.05).
Conclusion:This study provides the evidence that genus Actinomyces and genus Streptococcus are causally associated with PCOS.
- Full text:2024100811213748742肠道菌群与多囊卵巢综合征的孟德尔随机化研究.pdf
