Association between inflammatory factors and breast cancer: a Mendelian randomization study
10.19485/j.cnki.issn2096-5087.2024.08.016
- Author:
SONG Wenfu
;
GUAN Xutao
;
WANG Bing
;
SUN Shiling
;
LI Yingying
- Publication Type:Journal Article
- Keywords:
breast cancer;
inflammatory factor;
oncostatin-M;
Mendelian randomization;
genome-wide association studies;
causal relationship
- From:
Journal of Preventive Medicine
2024;36(8):714-717,722
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the causal relationship between inflammatory factors and breast cancer using two-sample Mendelian randomization (MR) approach, so as to provide the basis for the prevention and treatment of breast cancer.
Methods:Data of 91 inflammatory cytokines (n=14 824) and 5 subtypes of breast cancer (n=247 173) were collected from genome-wide association studies (GWAS). Single nucleotide polymorphism (SNP) associated with 91 inflammatory factors were selected as instrumental variables. MR analyses were performed using the inverse-variance weighted (IVW) method with inflammatory factors as exposure factors and breast cancer as outcome variables. The risk of type I error and the effect of multiple testing were reduced using the FDR correction method. The stability and reliability of the results were verified using Steiger test of directionality, MR-Egger regression, MR-PRESSO test and leave-one out method.
Results:Twenty-three inflammatory factors, including β nerve growth factor, interleukin-5, cystatin D and C-X-C chemokine ligand 1 were statistically associated with breast cancer (all P<0.05). After FDR adjustment, only evaluated abundance of oncostatin-M was found to be statistically associated with an increased risk of Basal-like (triple-negative) breast cancer (OR=1.186, 95%CI: 1.081-1.302, P=0.001, q=0.029), and the other 22 inflammatory factors had a high risk of type I error (all q>0.1). The sensitivity analysis indicated that the results were robust. No instrumental variables were found to have a significant impact on the results, which could exclude the influence of heterogeneity, horizontal pleiotropy, and reverse causality on the outcome.
Conclusion:The increased abundance of oncostatin-M may increase the risk of Basal-like (triple-negative) breast cancer.
- Full text:2024100809393494167炎症因子与乳腺癌关系的孟德尔随机化研究.pdf
