Exploration of the Inflammatory Mechanisms of Astrocytes in Neurodegenerative Diseases
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20240827.001
- VernacularTitle:星形胶质细胞在神经退行性疾病中的炎症机制探析
- Author:
Yan LIU
1
;
Xingang DONG
Author Information
1. 河南中医药大学康复医学院,河南 郑州 450046
- Keywords:
neurodegenerative diseases;
neuroinflammation;
astrocytes;
neurons;
microglia;
oligodendrocyte;
immune cells
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2024;45(5):764-776
- CountryChina
- Language:Chinese
-
Abstract:
As the global population continues to age,the incidence of neurodegenerative diseases has seen a constant increase in the elderly.Research indicates that neuroinflammation is a significant pathological mechanism in neurodegenerative diseases such as Alzheimer's disease,Parkinson's disease,amyotrophic lateral sclerosis,multiple sclerosis and Huntington's disease.Astrocytes are key glial cells involved in the regulation of neuroinflammation.More studies have revealed that astrocytes closely interact with other glial cells,neurons and peripheral immune cells to regulate synaptic plasticity,neuronal function,glutamate cycling and energy metabolism in the central nervous system,which shows notable therapeutic effects on neurodegenerative diseases.This paper aims to further explore specific manifestations and potential molecular mechanisms of astrocyte-mediated inflammatory processes in neurodegenerative diseases through interactions of astrocytes and other cells,therefore to identify new therapeutic targets from the perspective of astrocytes and then improve the symptoms.
