Genetic Polymorphism of 42 Autosomal STR Loci from Chinese Han Population in Shenzhen
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.20240907.016
- VernacularTitle:深圳汉族人群42个常染色体短串联重复序列基因座的遗传多态性
- Author:
Yanping ZHONG
1
;
Litao WU
1
;
Zhen LI
1
;
Dan ZHOU
1
;
Zhanrou QUAN
1
;
Shuang LIANG
1
;
Zhihui DENG
1
;
Yinming ZHANG
1
Author Information
1. Institute of Transfusion Medicine， Shenzhen Blood Center， Shenzhen 518040， China
- Publication Type:Journal Article
- Keywords:
forensic genetics;
genetic polymorphism;
autosome;
short tandem repeats;
Shenzhen;
Han population
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2024;45(5):739-744
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the genetic polymorphism of 42 short tandem repeats （STRs）， including 41 non-CODIS loci from the Shenzhen Han population and evaluate their potential values in forensic application. MethodsIn our research， the AGCU 21+1 STR kit and Microreader™ 23sp Direct ID System were applied to analyze the polymorphism of STR loci from 435 unrelated individuals of Shenzhen Han population. Modified-Powerstates and Arlequin v3.5 software were used to analyze the allele frequencies and forensic parameters， and perform the Hardy-Weinberg equilibrium test. ResultsA total of 418 alleles were detected from 435 unrelated individuals in Shenzhen， all consistent with Hardy-Weinberg equilibrium （P>0.05/42）， with the allele frequency ranging from 0.001 1 to 0.552 9. Besides， the discrimination power （DP） ranged from 0.798 8 （D1S1627） to 0.968 6 （D7S3048）， the polymorphic information content （PIC） ranged from 0.568 0 （D1S1627） to 0.859 8 （D7S3048）， and the heterozygosity （H） ranged from 0.627 6 （D1S1627） to 0.878 2 （D20S470）. Among all the STRs tested in the study， both D1S1656 and D21S1270 have 16 alleles and show the highest polymorphism. In comparison， only five alleles were observed in the D4S2408 locus， which displays the least polymorphism. ConclusionsThe 42 autosomal STR loci with high genetic polymorphism in Shenzhen Han population showed potential as an effective means for individual identification and paternity testing， especially in the cases with single parent or mutation detected. The obtained information can provide basic data for STR population genetics.
