Research Progress on Estrogen and Candidalysin in Vulvovaginal Candidiasis

VernacularTitle:雌激素和Candidalysin在外阴阴道念珠菌病中的研究进展
Author: Tingting XIA ^{1
,

2} ; Huaiqiu HUANG
Author Information

1. 中山大学附属第三医院生殖医学中心,广东广州,510630
2. 中山大学附属第三医院皮肤与整形美容科,广东广州,510630
Keywords: Candida albicans; vulvovaginal candidiasis; estrogen; Candidalysin; inflammation
From: Journal of Sun Yat-sen University(Medical Sciences) 2024;45(5):677-682
CountryChina
Language:Chinese
Abstract: Candida albicans(CA)is the predominant cause of vulvovaginal Candidiasis(VVC).Increasing circulatory estrogen levels such as pregnancy,the use of oral contraceptives,and hormone replacement therapy predispose women to VVC.Estrogen affects the progression of VVC by regulating the growth of CA hyphae,the immune response of the innate immune cells and epithelial cells of host vaginal,but the mechanism is unclear till now.Candidalysin(CL)is a fungal peptide toxin critical for mucosal infection and plays an important role in the CA infection.CL was encoded by ECE1,which was regulated by estrogen.This article reviews the correlation between estrogen,CL,and VVC for further clarifying the role of estrogen and CL in the pathogenesis of VVC.