Investigation on pathogenic characteristics of hand, foot and mouth disease cases and enterovirus 71 antibody levels in healthy people in Xi'an in 2022
10.3969/j.issn.1006-2483.2024.05.032
- VernacularTitle:2022年西安市手足口病的病原构成与EV-A71抗体调查
- Author:
Zerun XUE
1
,
2
;
Hailong CHEN
1
,
2
;
Quanli DU
1
,
2
;
Yuewen HAN
1
,
2
;
Shuling LI
1
,
2
;
Yuanyuan DUAN
1
,
2
;
Rui WU
1
,
2
Author Information
1. Xi'
2. an Municipal Center for Disease Control and Prevention , Xi'an , Shaanxi 710054 , China
- Publication Type:Journal Article
- Keywords:
Hand, foot and mouth disease;
Etiology;
Enterovirus 71;
Antibody level
- From:
Journal of Public Health and Preventive Medicine
2024;35(5):134-137
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the pathogenic composition of hand, foot and mouth disease (HFMD) cases and the antibody level of enterovirus 71 (EV-A71) in healthy people in Xi'an in 2022, so as to provide evidence for the prevention and control of HFMD. Methods Anal swabs or stool specimens of HFMD cases were collected. RT-PCR was used to detect enterovirus (EV) and serotype was identified. Enzyme-linked immunosorbent assay (ELISA) was used to detect EV-A71 IgG antibody levels in healthy people. Results A total of 172 positive cases were detected from 274 HFMD clinical specimens with a total detection rate of 62.77%, including 1 case of EV-A71 (0.58%), 95 cases of CV-A16 (55.23%), 64 cases of CV-A6 (37.21%), and 1 case of CV-A10(0.58%). CV-A16 was the dominant pathogen in spring and summer, and CV-A6 was the dominant pathogen in autumn and winter（χ2= 64.376，P＜0.001）. The age of HFMD cases caused by CV-A16 was older than the cases caused by CV-A6（t = 2.709，P = 0.007）. The positive rate of EV-A71 IgG antibodies in healthy people was 36.92% (168/455). The positive rate of EV-A71 IgG antibodies in men (32.35%) was lower than that in women (43.72%), and the difference was statistically significant (χ2= 6.605 , P = 0.014). The positive rate of EV-A71 IgG antibodies in people of all ages ranged from 21.95% to 54.78%, and the difference was statistically significant (χ2= 27.623 , P<0.001). Conclusion The main pathogens of hand, foot and mouth disease in Xi'an in 2022 are CV-A16 and CV-A6 . The positive rate of EV-A71 IgG antibodies in children under 5 years old is low , and EV-A71 vaccination should be strengthened.
