Characteristics of human papillomavirus prevalence and genotype distribution of 18 535 cases in Yuncheng
10.3969/j.issn.1006-2483.2024.05.027
- VernacularTitle:运城地区18 535例人乳头瘤病毒感染现状及亚型分布特征分析
- Author:
Wugang SUN
1
;
Haitao XIE
1
;
Xiali CHEN
2
;
Zhonghua LUAN
1
;
Mengxin LU
1
Author Information
1. Department of Pathology , Yuncheng Central Hospital , Yuncheng , Shanxi 044000 , China
2. Medical Department , Yuncheng Central Hospital , Yuncheng , Shanxi 044000 , China
- Publication Type:Journal Article
- Keywords:
Human papillomavirus;
Genotype distribution;
Prevalence;
Distribution characteristics
- From:
Journal of Public Health and Preventive Medicine
2024;35(5):113-116
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of human papillomavirus (HPV) prevalence and genotype distribution of 18 535 cases in Yuncheng . Methods A sample of 18535 residents who underwent HPV testing in our hospital from August 2020 to September 2023 were enrolled, and HPV genotyping was done to all samples. Then the rate of HPV infection, age distribution, genotype distribution, and multiple infections were statistically analyzed. Results Of the 18,535 subjects included, a total of 4,639 tested positive for HPV, demonstrating a positive rate of 25.03%. The positive rate of HPV infection varied among different age groups (χ2=29.587, P<0.05), with higher rates found in <25 years old group (29.61%) and >60 years old group (25.89%). Overall, 23 genotypes, covering 5315 viruses, were detected. There were 5 low-risk genotypes with the highest percentage of HPV42 (9.29%), and there were 18 high-risk genotypes with HPV52, HPV58, HPV66 and HPV53, subtypes as the most frequent subtypes, accounting for 13.64%, 8.97%, 7.41% and 7.04%, respectively. The type of HPV infection was predominantly single infections, with an overall single infection rate of 21.62% (4008/18535), which accounted for 86.40% (4 008/4 639) of all positive cases, and a multiple genotype infections rate of 3.40% (631/18535). The 25-34 year old group accounted for the largest proportion of single infections (25.12%), while the <25 year old group accounted for the largest proportion of multiple genotype infections (30.74%). Conclusion The prevalence rate of HPV infection in Yuncheng is 25.03%, with a higher positive rate in the <25 years age group and the >60 years age group. A total of 23 HPV genotypes are detected, of which the main genotypes are HPV42, HPV58, HPV66 and HPV53, and the type of infection is dominated by single infections.
