Changes of coagulation function and other indicators of the thawed FFP and FLP at 2-6℃
10.13303/j.cjbt.issn.1004549x.2024.09.014
- VernacularTitle:融化后的FFP、新鲜液体血浆在2～6℃环境中储存凝血功能等指标的变化
- Author:
Jie PAN
1
;
Xiangyun YAN
1
;
Zhiyong LU
1
;
Danhong WANG
1
;
Qianqian CHEN
1
;
Hongjie CHEN
1
;
Yuting RUAN
1
Author Information
1. Taizhou Blood Center, Taizhou 318000, China
- Publication Type:Journal Article
- Keywords:
fresh frozen plasma (FFP);
fresh liquid plasma (FLP);
storage time;
FⅤ;
FⅧ
- From:
Chinese Journal of Blood Transfusion
2024;37(9):1047-1051
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To observe the changes of coagulation factor activity and protein content of the thawed fresh frozen plasma (FFP) and fresh liquid plasma (FLP) during storage at 2-6℃, and to provide reference for exploring the appropriate storage time of FFP at 2-6℃ after thawing. 【Methods】 The small-thaw group and the large-thaw group were respectively detected for the activity of coagulation factor FⅤ (FⅤ∶C) and FⅧ(FⅧ∶C), and the levels of fibrinogen (Fib), total protein (TP) and albumin (Alb) in TTP at 1, 2, 3, 4, 5, 6 and 7 days after thawing. And the FLP was detected for FⅤ∶C, FⅧ∶C, Fib, TP and Alb at 1, 2, 3, 4, 5, 6, 7 days and 1, 6, 11, 16, 21, 26 and 31 days after preparation, respectively. 【Results】 In FFP group, FⅧ∶C decreased gradually with the prolongation of storage time after melting (P<0.05), and decreased by 37.4% and 47.6% respectively in the two groups on the 7th day. There was no statistical difference in FⅤ∶C, Fib, TP and Alb (P>0.05). In FLP group, FⅧ∶C decreased gradually with the prolongation of storage time after melting (P<0.05). There was no statistical difference in FⅤ∶C in 7-day storage group (P>0.05), but it decreased gradually in 31-day storage group (P<0.05). There was no statistical difference in Fib, TP and Alb (P>0.05). 【Conclusion】 Although FⅧ∶C is decreased in thawed FFP stored at 2-6℃ for 7 days, it is still about 52.4%, which should be able to play a normal role in clinical practice.
