Clinical observation of autologous platelet-rich plasma eye drops in the treatment of dry eye syndrome
10.13303/j.cjbt.issn.1004549x.2024.09.006
- VernacularTitle:自体富血小板血浆滴眼液治疗干眼症的临床疗效观察
- Author:
Yan BAI
1
;
Jing LI
2
;
Guiqiu SHAN
3
;
Yeshan LIU
1
;
Yingzhi LIU
4
Author Information
1. Department of Transfusion, Jingdong Sino-American Hospital, Langfang 065200, China
2. Department of Transfusion, 923 Hospital of the Chinese People's Liberation Army Joint Logistic Support Force
3. Department of Transfusion, Southern Theater Command General Hospita
4. Department of Ophthalmology, Liuzhi People's Health Hospital
- Publication Type:Journal Article
- Keywords:
autologous platelet-rich plasma(PRP);
dry eye syndrome;
clinical effect
- From:
Chinese Journal of Blood Transfusion
2024;37(9):1003-1007
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the effect of autologous platelet-rich plasma(PRP) in the treatment of dry eye syndrome. 【Methods】 A total of 64 patients with dry eye treated in the Ophthalmology Department of Jingdong Sino-American Hospital of Hebei Province from March to November 2023 were randomly selected for the study. The patients were divided into observation group and control group according to the random number table method, with 32 cases and 64 eyes in each group. The control group was treated with artificial tears of polyvinyl alcohol without preservatives, and the observation group was treated with PRP eye drops. The clinical efficacy and adverse reactions of the two groups were compared. Overall efficacy, duration of symptom resolution, ocular surface disease index (OSDI), tear film break up time (TBUT), schirmer's test(St) and corneal fluorescein staining (CFS) results of the two groups were observed and compared in 4 weeks. 【Results】 After 4 weeks of treatment, the total effective rate of observation group was 96.88%(31/32), which was significantly higher than that of control group 84.38%(27/32), with statistical significance (P<0.05). After treatment, the St, TBUT, CFS, OSDI and lacrimal river height in observation group were significantly superior to control group, with statistical significance (P<0.05). The disappearance time of dryness, visual fatigue and foreign body sensation in the observation group was shorter than that in the control group, and the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was 46.875%(15/32), and there was no significant difference between the observation group and the control group. 【Conclusion】 Autologous PRP is an effective and safe choice for the treatment of dry eye syndrome, which is worthy of further study and confirmation.
