Heart rate variability in obese patients with severe obstructive sleep apnea hypopnea syndrome

Yuqi Yuan; Lina MA; Yonglong SU; Xiaoxin Niu; Yushan Xie; Haiqin Liu; Xiaoyong Ren; Yewen Shi

Return

Heart rate variability in obese patients with severe obstructive sleep apnea hypopnea syndrome

VernacularTitle:肥胖合并重度阻塞性睡眠呼吸暂停低通气综合征患者的心率变异性分析
Author: Yuqi YUAN ¹ ; Lina MA ¹ ; Yonglong SU ¹ ; Xiaoxin NIU ¹ ; Yushan XIE ¹ ; Haiqin LIU ¹ ; Xiaoyong REN ¹ ; Yewen SHI ¹
Author Information

1. Department of Otorhinolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
Publication Type:Journal Article
Keywords: obese; severe obstructive sleep apnea hypopnea syndrome (severe OSAHS); heart rate variability (HRV); autonomic nervous system
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2024;45(5):757-762
CountryChina
Language:Chinese
Abstract: 【Objective】 To investigate the characteristics of heart rate variability (HRV) in obese patients with severe obstructive sleep apnea hypopnea syndrome (OSAHS). 【Methods】 We retrospectively analyzed 78 patients with severe OSAHS diagnosed by polysomnography (PSG) in The Second Affiliated Hospital of Xi’an Jiaotong University from April 2018 to May 2022. According to body mass index (BMI), the patients were divided into obese with severe OSAHS group (43 cases) and non-obese with severe OSAHS group (35 cases). All patients received 24-hour Holter monitoring while on polysomnography monitoring. The differences in HRV indexes between the groups and the correlation between HRV and clinical indicators were analyzed. 【Results】 In terms of basic data and PSG indexes, the analysis results showed that compared with those in the non-obese OSAHS group, weight, BMI, neck circumference, waist circumference, and AHI in obese with severe OSAHS group were significantly higher, while the standard deviation of the 24-hour normal R-R interval (SDNN), the standard deviation of the 5-minute mean (SDANN), the triangle index (TI), the heart rate deceleration force (DC), the standard deviation of the normal R-R interval (awake SDNN), and high frequency during sleep in the obese with severe OSAHS group were significantly lower (P<0.05). The correlation results showed that among obese with severe OSAHS patients, root mean square of the difference of adjacent R-R interval (rMSSD) was negatively correlated with the course of hypertension; TI and DC were negatively correlated with AHI. After adjusting for neck circumference and waist circumference, the linear regression analysis showed that SDNN, SDANN, and rMSSD were correlated with systolic blood pressure (P<0.05). 【Conclusion】 There is significant decrease in HRV index in obese patients with severe OSAHS, suggesting that deterioration of cardiac autonomic nervous regulation function may increase the risk of cardiovascular disease.