Research progress on ferroptosis in the treatment of bladder cancer
10.3969/j.issn.1009-8291.2024.09.016
- VernacularTitle:铁死亡在膀胱癌治疗中的研究进展
- Author:
Jingping QIU
1
;
Lugang ZHU
1
;
Yuanwei CHEN
1
;
Minghong ZHOU
1
;
Yuwan ZHAO
1
;
Jianjun LIU
1
Author Information
1. Department of Urology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
- Publication Type:Journal Article
- Keywords:
bladder cancer;
ferroptosis;
amino acid metabolism;
non-coding RNA;
N6-methyladenosine;
autophagy
- From:
Journal of Modern Urology
2024;29(9):830-835
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a new programmed cell death dependent on iron ions.Ferroptosis can be induced by endogenous or exogenous pathways, and cells exhibit specific cell morphological signs and are regulated by a variety of molecular mechanisms.In recent years, more and more studies have shown that ferroptosis plays an important role in the treatment of cancer.This article summarizes the mechanism of ferroptosis in bladder cancer and the regulation of cancer cells, as well as the role of ferroptosis-related factors, non-coding RNA regulation, N6-methyladenosine (m6A), amino acid metabolism and autophagy dependent ferroptosis in the growth and proliferation of bladder cancer, with a view to provide new strategies for the treatment of bladder cancer.
