Detection and analysis of brain function in patients with pelvic floor overactive bladder by resting state functional magnetic resonance imaging with amplitude of low-frequency fluctuation
10.3969/j.issn.1009-8291.2024.09.007
- VernacularTitle:脑部静息态功能磁共振低频振幅法检测盆底膀胱过度活动症患者大脑各区功能及结果分析
- Author:
Zhongqing WEI
1
,
2
;
Yunpeng LI
1
;
Chunlong LI
1
;
Sumin ZHAO
3
;
Liucheng DING
1
;
Sicong ZHANG
1
;
Qingbing ZHANG
4
;
Qiang XIA
5
Author Information
1. Department of Pelvic Floor Surgery and Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210000
2. Department of Urology, Wuxi Ninth Affiliated Hospital of Suzhou University, Wuxi 214100
3. Imaging Department, Dong’ e County People’s Hospital, Liaocheng 252200
4. Department of Urology, Dong’ e County People’s Hospital, Liaocheng 252200, China
5. Department of Urology, Wuxi Ninth Affiliated Hospital of Suzhou University, Wuxi 214100
- Publication Type:Journal Article
- Keywords:
resting state functional magnetic resonance imaging;
overactive bladder;
amplitude of low-frequency fluctuation;
brain functional areas
- From:
Journal of Modern Urology
2024;29(9):781-784
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 The amplitude of low-frequency fluctuation (ALFF) resting state functional magnetic resonance imaging (rs-fMRI) was used to investigate the signals image in the brain functional areas of overactive bladder (OAB) patients. 【Methods】 OAB patients treated in 3 participating hospitals during Mar.2021 and Mar.2023 were selected as the OAB group (n=14).Healthy subjects matching the gender, age and years of education of the patients in the OAB group were collected as the control group (NC group, n=14).Changes in the over active bladder symptom score (OABSS), quality of life scale (QoL), self-rating depression scale (SDS), self-rating anxiety scale (SAS) were analyzed.All subjects underwent rs-fMRI to collect blood oxygen level dependent magnetic resonance signals, which were then processed with ALFF.Two-sample t-test was conducted on the results to obtain the different brain regions. 【Results】 The OABSS \[(8.07±0.37) vs. (1.21±0.18)\], QoL \[(4.85±0.21) vs. (0.64±0.13)\], SAS \[(60.14±1.40) vs.(37.64±1.57)\] and SDS \[(52.50±1.29) vs.(36.14±0.34)\] scores of the OAB group were higher than those of the NC group, with significant differences (P<0.05).The brain regions with significant differences in ALFF were located in the left supplementary motor area, left medial superior frontal gyrus and right anterior central gyrus (P<0.000 1). 【Conclusion】 The abnormal spontaneous activity and coordination ability of the brain in resting state may lead to OAB symptoms, which are displayed in the abnormal functions of the left supplementary motor area, left medial superior frontal gyrus and right anterior central gyrus.
