Research progress of photodynamic technology in precision diagnosis and treatment of bladder cancer
10.3969/j.issn.1009-8291.2024.08.017
- VernacularTitle:光动力技术介导膀胱癌精准诊疗的研究进展
- Author:
Haiming KANG
1
;
Pengyu YAN
1
;
Xiaofeng YANG
2
Author Information
1. The First Clinical Medical College, The First Hospital, Shanxi Medical University, Taiyuan 030000, China
2. Department of Urology, The First Hospital, Shanxi Medical University, Taiyuan 030000, China
- Publication Type:Journal Article
- Keywords:
bladder cancer;
photodynamic technology;
photodynamic diagnostics;
photodynamic therapy;
blue light cystoscopy;
photosensitizers;
nanotechnology;
targeted technology;
targeted molecular tracers
- From:
Journal of Modern Urology
2024;29(8):744-749
- CountryChina
- Language:Chinese
-
Abstract:
Bladder cancer is one of the common malignant tumors of the urinary system, and the results of conventional diagnosis and treatment methods are not satisfactory at this stage.In recent years, photodynamic technology has been applied in the diagnosis and treatment of bladder cancer due to its rapid development, and its effect has been widely recognized in clinical practice. Photodynamic diagnosis (PDD) has shown value in the diagnosis of bladder cancer, and compared with white light cystoscopy (WLC), blue light cystoscopy (BLC) has higher sensitivity and specificity, and is better suitable for the diagnosis of minor lesions and hidden lesions such as CIS, but it is expensive and time-consuming.Non-invasive targeted photodynamic diagnostic techniques using urine as a sample are beginning to show potential; PDD-guided TURBT has better diagnostic sensitivity and surgical precision. Photodynamic therapy (PDT) is an ideal treatment modality for bladder cancer.New photosensitizers have been developed, and two-photon PDT technology, intermittent and rhythmic PDT technology have been applied, which can help to reduce the number of PDT operations and reduce additional trauma while improving the efficacy.Some scholars have tried to use nanotechnology to combine PDT with chemotherapy drugs to further improve the efficacy.Monoclonal antibodies, antibody fragments, protein scaffolds, peptides and small molecule targeted molecular tracers have different characteristics, and new combination therapy methods are being researched and developed, bringing new opportunities for bladder cancer treatment.
