Survival outcomes of bladder cancer with non-pure urothelium: a propensity score matching analysis
10.3969/j.issn.1009-8291.2024.08.003
- VernacularTitle:基于倾向性评分匹配法的非单纯尿路上皮型膀胱癌行机器人辅助下根治性膀胱切除术后生存分析
- Author:
Yulin ZHANG
1
;
Jiazheng LI
2
;
Zihan ZHAO
1
;
Xiaogong LI
1
;
Shiwei ZHANG
1
;
Gutian ZHANG
1
;
Hongqian GUO
1
;
Rong YANG
1
Author Information
1. Department of Urology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008
2. Drum Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210008, China
- Publication Type:Journal Article
- Keywords:
propensity score matching;
bladder cancer;
bladder cancer with non-pure urothelium;
bladder cancer with pure urothelium
- From:
Journal of Modern Urology
2024;29(8):673-679
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To compare the survival outcomes of bladder cancer with non-pure urothelium (BCa with n-pU) and bladder cancer with pure urothelium (BCa with pU) treated with robot-assisted radical cystectomy (RARC). 【Methods】 Clinical data of BCa patients treated with RARC in Nanjing Drum Tower Hospital during Oct.2014 and Mar.2022 were retrospectively analyzed.The patients were divided into n-pU group and pU group.After the baseline differences between groups were balanced with propensity score matching (PSM), the overall survival (OS) and recurrence-free survival (RFS) curve were plotted using Kaplan-Meier method and compared using Log-rank test.Univariate and multivariate analysis were performed with Cox model to identify the influencing factors of prognosis.Based on the results, a secondary grouping was performed to compare the survival differences between subgroups and further investigate the prognostic factors. 【Results】 After PSM, there were 53 pairs of BCa patients.There were no significant differences in the baseline data between the pU and n-pU groups (P<0.05).Regardless of T stage, there were no significant differences in OS and RFS between the two groups (P=0.217, P=0.109).Univariate Cox regression analysis showed that T stage (>T2) was a significant risk factor of OS and RFS(P<0.05).In the early pathological stage (≤T2), there were no significant differences in OS and RFS (P=0.565, P=0.344).In the advanced pathological stage (>T2), the OS and RFS of n-pU were significantly worse than those of pU patients (P=0.025, P=0.034). 【Conclusion】 The prognosis of BCa patients with n-pU who received RARC is significantly correlated with pathological status.At >T2 stage, n-pU patients have worse prognosis than pU patients in the same pathological status.
