Establishing and validating a nomogram model for predicting the prognosis of bladder cancer patients based on the score of systemic inflammatory markers before radical cystectomy combined with pathological T stage
10.3969/j.issn.1009-8291.2024.06.012
- VernacularTitle:术前系统性炎症标志物评分联合病理T分期预测根治性膀胱切除术后膀胱癌患者预后列线图模型的建立与验证
- Author:
Gang LI
1
,
2
;
Hailong LI
;
Zewei WANG
;
Zhimin GAO
;
Rumin WEN
Author Information
1. 徐州医科大学附属医院泌尿外科,江苏徐州 221000
2. 徐州医科大学研究生院,江苏徐州 221004
- Keywords:
bladder cancer;
systemic inflammatory markers;
prognosis;
nomogram model;
pathological T staging
- From:
Journal of Modern Urology
2024;29(6):533-539
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of systemic inflammatory markers(SIM)in the prognosis of patients with bladder cancer undergoing radical cystectomy.Methods Clinical data of 233 patients with bladder cancer who underwent radical cystectomy in the Affiliated Hospital of Xuzhou Medical University during Dec.2011 and Nov.2020 were retrospectively collected,the SIM score was calculated and patients were grouped.Progression-free survival(PFS)was assessed with Kaplan-Meier analysis,and differences between groups were compared with log-rank test.Factors affecting PFS were analyzed with Cox proportional risk model.The patients were randomly divided into a training set(n=164)and a verification set(n=69)according to 7:3 ratio,and a nomogram model was established and verified.Results Cox regression analysis showed that SIM score and pathological T staging were independent predictors of PFS(P＜0.05).A predictive model was established based on SIM score and pathological T staging.The area under the receiver operating characteristic(AUC)curve for predicting 1-year,3-year,and 5-year PFS were 0.939,0.943,and 0.943,respectively.After the model was applied to evaluate the validation set,the performance was still stable.Conclusion The prediction model based on SIM score and clinicopathological T staging can accurately predict the survival of patients with bladder cancer after radical cystectomy,and can be used to guide individualized treatment of patients.
