Diagnostic value of liquid-based cytology targeted FISH for urothelial carcinoma of the bladder
10.3969/j.issn.1009-8291.2024.06.007
- VernacularTitle:尿液基细胞荧光原位杂交检测对膀胱尿路上皮癌的诊断价值
- Author:
Yongjin HUANG
1
;
Zhibin LIU
1
;
Gehong DONG
2
;
Xuanyan CHE
1
;
Yong ZHANG
1
Author Information
1. Department of Urology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
2. Department of Pathology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
- Publication Type:Journal Article
- Keywords:
urothelial carcinoma of the bladder;
fluorescence in situ hybridization;
nuclear matrix protein 22;
urinary liquid-based cytology
- From:
Journal of Modern Urology
2024;29(6):505-509
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the diagnostic value of urinary liquid-based cytology (LBC) targeted fluorescence in situ hybridization (FISH) for urothelial carcinoma of the bladder. 【Methods】 Nuclear matrix protein 22 (NMP22) detection, urinary LBC and FISH were performed in 128 patients.The sensitivity and specificity of the three kinds of tests were analyzed with postoperative pathological results as the gold standard. 【Results】 The sensitivity of NMP22, urinary LBC and FISH was 61.11%, 79.17% and 82.46%, the specificity was 57.14%, 73.21% and 86.67%, respectively.The sensitivity of NMP22 and urinary LBC in detecting high BUC was better than that of low BUC, and the difference was statistically significant (P=0.01, P=0.03).There was no significant difference in the sensitivity of the three tests for the diagnosis of muscle-invasive bladder cancer and non muscle-invasive bladder cancer (P≥0.05). 【Conclusion】 Urinary LBC targeted FISH has high sensitivity and specificity in the diagnosis of urothelial carcinoma of the bladder and low-grade urothelial carcinoma.It can be an important method for the early screening and diagnosis of bladder cancer.
