Continuous saline bladder irrigation after a single instillation of chemotherapy increases the risk of progression of low- and immediate-risk non-muscle-invasive bladder cancer
10.3969/j.issn.1009-8291.2024.06.002
- VernacularTitle:单次灌注化疗后膀胱持续生理盐水冲洗或增加中低风险非肌层浸润性膀胱癌进展风险
- Author:
Fei WANG
1
;
Yiqing DU
1
;
Caipeng QIN
1
;
Qing LI
1
;
Shijun LIU
1
;
Tao XU
1
Author Information
1. Department of Urology, Peking University People’s Hospital, Beijing 100044, China
- Publication Type:Journal Article
- Keywords:
bladder cancer;
single immediate instillation of chemotherapy;
continuous saline bladder irrigation;
intravesical recurrence;
tumor progression
- From:
Journal of Modern Urology
2024;29(6):481-485
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the efficacy of continuous saline bladder irrigation (CSBI) after a single immediate instillation of chemotherapy (SIIC) in patients with low- and immediate-risk non-muscle-invasive bladder cancer (NMIBC) undergoing transurethral resection of bladder tumor (TURBT). 【Methods】 Clinical data of 211 patients with with low- and immediate-risk NMIBC, who underwent TURBT in our hospital during Jan.2004 and Dec.2019 were collected.The patients were divided into two groups according to whether CSBI was conducted after SIIC.The recurrence rate, progression rate, recurrence-free survival and progression-free survival of the two groups were compared.Cox univariate and multivariate regression analyses were used to investigate whether CSBI was a risk factor for recurrence and progression. 【Results】 There were no significant differences in baseline data, recurrence rate and progression rate between the two groups (P>0.05).There was no significant difference in recurrence-free survival between the two groups, but the progression-free survival was shorter in CSBI group (χ2=8.270, P=0.004) .Multivariate Cox regression analysis indicated that diabetes (HR: 2.240, 95%CI:1.066-4.704, P=0.033) and multiple tumors (HR: 3.060, 95%CI: 1.639-5.711, P<0.001) were independent risk factors for recurrence and CSBI(HR: 7.914, 95%CI: 1.710-36.632, P=0.008) was an independent risk factor for progression. 【Conclusion】 CSBI after SIIC may increase the risk of progression in patients with low- and immediate-risk NMIBC, but a larger sample size is needed for validation.
