Bladder hypersensitivity:the new mechanism of overactive bladder occurrence

VernacularTitle:膀胱感觉过敏——膀胱过度活动症发生的新机制
Author: Lingchen KONG ¹ ; Yongxiang SHAO ; Jizong LYU ; Guanyu WU ; Zilong LIANG ; Haofeng PANG ; Fei LIU
Author Information

1. 空军军医大学西京医院泌尿外科,陕西西安 710032
Keywords: bladder sensation; overactive bladder; receptor; ion channel; bladder pressure; nerve fiber
From: Journal of Modern Urology 2024;29(5):471-475
CountryChina
Language:Chinese
Abstract: In recent years,with in-depth study of bladder sensation related mechanisms,numerous ion channels,neurotransmitters and nerve receptors have been found to participate in the regulation of bladder sensation,including TRPV,P2X and Piezo,as well as CBR and HCN.Thanks to the relevant research on the neural signal pathway from the cerebral cortex to the bladder wall and the maturity of clinical measurement methods for bladder sensation,we can further study the abnormal bladder sensation in patients with overactive bladder(OAB),so as to explore its mechanism.Bladder hypersensitivity,as one of the current research hotspots,is receiving increasing attention from researchers.This article reviews the mechanism of bladder hypersensitivity from the aspects of clinical measurement methods of bladder sensation,ion channel,neurotransmitters and nerve receptors related to bladder sensation,in order to explore its significance in the pathogenesis of OAB.