Perioperative application of prucalopride in robot-assisted laparoscopic radical cystectomy and urinary diversion
10.3969/j.issn.1009-8291.2024.05.003
- VernacularTitle:普芦卡必利在机器人辅助腹腔镜根治性膀胱切除+尿流改道术围手术期应用的效果分析
- Author:
Fayun WEI
1
;
Ning JIANG
;
Huaying LIU
;
Baofu FENG
;
Shun ZHANG
;
Jiarong DING
;
Weidong GAN
;
Shiwei ZHANG
;
Hongqian GUO
;
Rong YANG
Author Information
1. 南京大学医学院附属鼓楼医院泌尿外科,江苏南京 210008
- Keywords:
bladder cancer;
robot-assisted laparoscopic radical cystectomy;
urinary diversion;
prucalopride;
post-operative ileus;
intestinal function;
perioperative period
- From:
Journal of Modern Urology
2024;29(5):394-398
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of prucalopride(PRUC)on the intestinal function during the perioperative period of robot-assisted laparoscopic radical cystectomy(RARC)and urinary diversion.Methods A total of 75 patients undertaking RARC with urinary diversion(orthotopic neobladder or ileal bladder)in Nanjing Drum Hospital during Jan.and Dec.2021 were divided into PRUC group(n=28)and control group(n=47)according to whether they took PRUC or not.Postoperative intestinal ventilation time and defecation time,drainage tube retention time,tolerance time for first intake of semi-flow food,postoperative hospital stay,and incidence of complications were observed and recorded in the two groups.Postoperative C-reactive protein(CRP)and neutrophil/lymphocyte ratio(NLR)were compared.Results The PRUC group had shorter intestinal ventilation time and defecation time[(47.14±16.31)h vs.(74.04±35.33)h,P＜0.01;(86.14±30.47)h vs.(123.57±79.12)h,P=0.02],smaller change of ΔCRP and ΔNLR[(79.99±29.71)mg/L vs.(127.75±56.98)mg/L;(9.24±6.43)vs.(16.11±9.90),P＜0.01].All complications were minor,the incidence of intestinal obstruction in PRUC group tended to decrease within 90 days after operation(P=0.38),and there was no significant difference in other complications between the two groups(P＞0.05).Conclusion The perioperative use of PRUC in RARC with urinary diversion is safe and effective,which can promote the recovery of intestinal function after operation.
