Perioperative application of prucalopride in robot-assisted laparoscopic radical cystectomy and urinary diversion
10.3969/j.issn.1009-8291.2024.05.003
- VernacularTitle:普芦卡必利在机器人辅助腹腔镜根治性膀胱切除+尿流改道术围手术期应用的效果分析
- Author:
Fayun WEI
1
;
Ning JIANG
2
;
Huaying LIU
3
;
Baofu FENG
4
;
Shun ZHANG
1
;
Jiarong DING
1
;
Weidong GAN
1
;
Shiwei ZHANG
1
;
Hongqian GUO
1
;
Rong YANG
1
,
5
,
6
,
7
Author Information
1. Department of Urology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008
2. Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing 210008
3. Department of Urology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing 210008
4. Department of Urology, The Affiliated Nanjing Drum Tower Hospital of Nanjing Medical University, Nanjing 210008, China
5. Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing 210008
6. Department of Urology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing 210008
7. Department of Urology, The Affiliated Nanjing Drum Tower Hospital of Nanjing Medical University, Nanjing 210008, China
- Publication Type:Journal Article
- Keywords:
bladder cancer;
robot-assisted laparoscopic radical cystectomy;
urinary diversion;
prucalopride;
post-operative ileus;
intestinal function;
perioperative period
- From:
Journal of Modern Urology
2024;29(5):394-398
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the effects of prucalopride (PRUC) on the intestinal function during the perioperative period of robot-assisted laparoscopic radical cystectomy (RARC) and urinary diversion. 【Methods】 A total of 75 patients undertaking RARC with urinary diversion (orthotopic neobladder or ileal bladder) in Nanjing Drum Hospital during Jan.and Dec.2021 were divided into PRUC group (n=28) and control group (n=47) according to whether they took PRUC or not.Postoperative intestinal ventilation time and defecation time, drainage tube retention time, tolerance time for first intake of semi-flow food, postoperative hospital stay, and incidence of complications were observed and recorded in the two groups.Postoperative C-reactive protein (CRP) and neutrophil/lymphocyte ratio (NLR) were compared. 【Results】 The PRUC group had shorter intestinal ventilation time and defecation time [(47.14±16.31) h vs.(74.04±35.33) h, P<0.01; (86.14±30.47) h vs.(123.57±79.12) h, P=0.02] , smaller change of ΔCRP and ΔNLR [(79.99±29.71) mg/L vs.(127.75±56.98) mg/L; (9.24±6.43) vs.(16.11±9.90), P<0.01] .All complications were minor, the incidence of intestinal obstruction in PRUC group tended to decrease within 90 days after operation (P=0.38), and there was no significant difference in other complications between the two groups (P>0.05). 【Conclusion】 The perioperative use of PRUC in RARC with urinary diversion is safe and effective, which can promote the recovery of intestinal function after operation.
