Research on the role of P2X receptor channel protein in the progression of solid tumors
- VernacularTitle:P2X嘌呤能受体通道蛋白参与实体瘤进展的研究
- Author:
Yuxuan QIN
1
;
Xingang CUI
1
Author Information
- Publication Type:Journal Article
- Keywords: P2X purinergic receptor; tumor microenvironment; adenosine triphosphate (ATP); solid tumor; targeted therapy
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2024;45(4):686-694
- CountryChina
- Language:Chinese
- Abstract: Adenosine triphosphate (ATP) is the most common energy supplier in living organisms and also an important signaling molecule. The expression level of ATP is significantly upregulated in the tumor microenvironment. The purinergic receptor ion channel P2X is widely distributed in various tissues. ATP can specifically activate the P2X receptor to induce the opening of gated ion channels in the microenvironment, thereby affecting the downstream signal transduction in regulating the physiological activities. Notably, abnormal purinergic signal plays an important role in tumor progression. This review focuses on the expression, structure, and function of the P2X receptor protein family. It also elucidates the mechanisms by which the P2X receptor family participates in the progression of various solid tumors, as well as research on targeted P2X family for tumor therapy. These studies will enrich the basic research theory related to purinergic signaling and provide the new targets and strategies for clinical therapy of solid tumors by targeting P2X family.
