Correlation between serum bile acid profile and cognitive function in patients with acute schizophrenia

Zhiyang QI; Qingyan MA; Min Jia; Binglong Wen; Wenhui Jiang; Xiancang MA; Yajuan Fan

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Correlation between serum bile acid profile and cognitive function in patients with acute schizophrenia

VernacularTitle:急性期精神分裂症患者血清胆汁酸谱与认知功能的相关性
Author: Zhiyang QI ¹ ; Qingyan MA ¹ ; Min JIA ¹ ; Binglong WEN ¹ ; Wenhui JIANG ¹ ; Xiancang MA ^{1
,

2} ; Yajuan FAN ^{1
,

2}
Author Information

1. Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061
2. Center for Brain Science, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
Publication Type:Journal Article
Keywords: schizophrenia; bile acid profile; cognitive function; neuroprotection
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2024;45(4):650-655
CountryChina
Language:Chinese
Abstract: 【Objective】 To investigate the effect of peripheral blood bile acids on the cognitive function of schizophrenia patients. 【Methods】 Targeted metabolomics was adopted to analyze the total level of primary and secondary serum bile acid metabolites collected from 23 schizophrenia patients and 23 health control individuals. The MATRICS Consensus Cognitive Battery (MCCB) was adopted to evaluate the subjects’ cognitive function in five dimensions. 【Results】 We found that the schizophrenia patients had impaired cognitive functions in multiple dimensions including speed of processing, working memory, reasoning and problem solving, and visual learning. Compared with the health control group, serum levels of cholic acid (CA) and chenodeoxycholic acid (CDCA) were significantly lower in patients with schizophrenia, while serum level of glycocholic acid (GCA) was significantly higher, and the ratio of deoxycholic acid (DCA) to CA was higher (3.04 vs. 1.16). Speed of processing, working memory, reasoning and problem solving, and visual learning abilities were significantly negatively correlated with serum levels of multiple primary bile acids including taurocholic acid (TCA), GCA, glycochenodeoxycholic acid (GCDCA) and taurochenodeoxycholic acid (TCDCA), after adjustments of age, sex, and body mass index. 【Conclusion】 The bile acid profile of schizophrenia patients is obvious, and the decrease in neuroprotective bile acids (namely, CA and CDCA) and the up-regulation of cytotoxic bile acid (i.e., GCA) may impair the cognitive function of schizophrenia patients.