Effect of Active Ingredients of Rehmanniae Radix in Intervening Acute Kidney Injury and Fibrosis： A Review
10.13422/j.cnki.syfjx.20241204
- VernacularTitle:地黄活性成分干预急性肾损伤和纤维化的研究进展
- Author:
Wenru WANG
1
;
Ying LIANG
1
;
Yao CHEN
1
;
Jingyi ZHAN
1
;
Tian ZHAN
1
;
Lei YAN
1
;
Fengzhao LIU
2
;
Jixin LI
1
;
Renhuan YU
1
Author Information
1. Xiyuan Hospital，China Academy of Chinese Medical Sciences，Beijing 100091，China
2. Shandong University of Traditional Chinese Medicine，Jinan 250355，China
- Publication Type:Journal Article
- Keywords:
Rehmanniae Radix;
acute kidney injury;
fibrosis;
mechanism of action;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(21):289-298
- CountryChina
- Language:Chinese
-
Abstract:
Acute kidney injury （AKI） is a clinical syndrome characterized by a rapid decline in renal function over a short period due to various etiologic factors. If left untreated， AKI can progress to chronic kidney disease （CKD） or even end-stage renal disease （ESRD）. Although continuous renal replacement therapy （CRRT） can manage severe AKI， effective pharmacological treatments for AKI remain largely unavailable. Chinese medicine， with its multi-target and multi-pathway approaches， has accumulated substantial theoretical and practical knowledge in treating AKI and related complications. Rehmanniae Radix is a commonly used Chinese medicinal， known for its functions in clearing heat， cooling blood， nourishing yin， and promoting fluid production. The primary active ingredients of Rehmanniae Radix include catalpol， acteoside， and aucubin. In this study， we summarized recent research on the effect of the active ingredients of Rehmanniae Radix in preventing and treating AKI. We found that the key mechanisms underlying its anti-AKI effects include amelioration of inflammation， alleviation of oxidative stress， and inhibition of apoptosis. Additionally， the antifibrotic properties of the active ingredients of Rehmanniae Radix suggest its potential in slowing CKD progression. We reviewed the mechanisms of Rehmanniae Radix in treating AKI and its antifibrotic effects to provide a scientific basis for developing new AKI drugs， promoting the utilization of Rehmanniae Radix resources， and reducing the transition from AKI to CKD.
