Mechanism of Small Molecules of Traditional Chinese Medicine Targeting Tumor-associated Macrophages in Gastrointestinal Tumors： A Review
10.13422/j.cnki.syfjx.20242491
- VernacularTitle:中药小分子靶向肿瘤相关巨噬细胞在消化道肿瘤的研究进展
- Author:
Yumeng CAI
1
;
Xiaoqing ZHANG
2
;
Gelei ZHAO
1
;
Shan ZHANG
1
;
Peimin LIU
1
;
Dongdong LI
1
Author Information
1. The Second Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450002，China
2. The First Affiliated Hospital of Zhengzhou University，Zhengzhou 50052，China
- Publication Type:Journal Article
- Keywords:
small molecules of traditional Chinese medicine（TCM）;
tumor-associated macrophages（TAMs）;
gastrointestinal tumors;
tumor microenvironment;
immune microenvironment;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(21):271-278
- CountryChina
- Language:Chinese
-
Abstract:
Tumor-associated macrophages （TAMs）， as the main immune cells in the human body， are key factors in maintaining the homeostasis of the tumor microenvironment. With high plasticity， they can polarize into the classically activated （M1） macrophages or alternatively activated （M2） macrophages under different conditions. M1 macrophages can inhibit tumor growth by phagocytosis， and M2 can inhibit the immune microenvironment to promote tumorigenesis and immune escape. Small molecules of traditional Chinese medicine have been widely studied in gastrointestinal tumors. These small molecules exert anti-tumor activity by enhancing TAM activity and promoting the polarization of macrophages. Targeted intervention in TAMs with these molecules has the potential to inhibit the development of gastrointestinal tumors. This article summarizes the research status and significance of small molecules of traditional Chinese medicine targeting TAMs against gastrointestinal tumors， aiming to provide reference for the future studies in this field.
