Traditional Chinese Medicine Treats Tumors via MAPK/NF-κB Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20241127
- VernacularTitle:中医药干预MAPK/NF-κB信号通路调控肿瘤作用机制的研究进展
- Author:
Lujiao WANG
1
;
Wentao SI
2
Author Information
1. Shandong University of Traditional Chinese Medicine（TCM）， Jinan 250355， China
2. Yantai Hospital of TCM， Yantai 264013， China
- Publication Type:Journal Article
- Keywords:
mitogen-activated protein kinase （MAPK）;
nuclear factor-κB （NF-κB）;
traditional Chinese medicine;
tumor;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(21):262-270
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumors， a group of serious diseases in China， endangers the health of the people. They are mainly treated by surgery， radiotherapy， chemotherapy， targeted therapy， and immunotherapy. With the development of precision medicine， targeted anti-tumor drugs have garnered increasing attention from researchers and gradually applied in clinical treatment. The mitogen-activated protein kinase （MAPK）/nuclear factor-κB （NF-κB） signaling pathway plays a key role in the occurrence and development of tumors， participating in the regulation of tumor microenvironment and the invasion， migration， proliferation， apoptosis， and drug resistance of tumor cells. Therefore， the key effectors targeting the regulation of the MAPK/NF-κB signaling pathway have become potential targets for the treatment of tumors. In China， traditional Chinese medicine （TCM） has become a key approach of tumor treatment since it can exert anti-tumor effects in a multi-component， multi-effect， multi-target， and multi-pathway manner， demonstrating definite clinical efficacy in tumor treatment. The available studies published in recent years have shown that the active components， herb pairs， and compound prescriptions of TCM can play an anti-tumor role by interfering with the MAPK/NF-κB signaling pathway， promoting apoptosis， inhibiting cell proliferation， blocking the cell cycle， inhibiting tumor invasion and metastasis and tumor stem cell characteristics， improving the immune function， and reversing tumor multi-drug resistance. However， a systematic review of the relevant studies remains to be conducted. This paper introduces the mechanism of tumor management via the MAPK/NF-κB pathway and reviews the research progress in TCM treatment of tumors via this pathway in recent years， aiming to provide a theoretical basis for the clinical application of anti-tumor TCM， drug development， and in-depth mechanism research.
