Therapeutic Effect of Bushen Huoxue Prescription on Diuretic Resistance in Chronic Heart Failure
10.13422/j.cnki.syfjx.20241124
- VernacularTitle:补肾活血方治疗慢性心力衰竭利尿剂抵抗的疗效观察
- Author:
Yuchen SUN
1
;
Yan ZHANG
2
;
Wenhao YIN
1
;
Shujun ZHAO
1
;
Muchen ZHANG
1
;
Guohua LIU
1
;
Yaqin WANG
1
;
Yilin ZHAO
1
Author Information
1. Liaoning University of Traditional Chinese Medicine（TCM）， Shenyang 110847， China
2. The Affiliated Hospital of Liaoning University of TCM， Shenyang 110032， China
- Publication Type:Journal Article
- Keywords:
chronic heart failure;
diuretic resistance;
Bushen Huoxue prescription;
inflammatory cytokines
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(21):123-129
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effects of Bushen Huoxue prescription on the cardiac function， inflammation， and quality of life of the patients with chronic heart failure resistant to diuretics. MethodA total of 78 patients who met the inclusion criteria were randomized into observation and control groups （39 cases）. Both groups received standardized treatment for diuretic resistance in accordance with the guidelines. In addition， the observation group received Bushen Huoxue prescription. The cardiac function indicators， total response rate regarding symptom alleviation， exercise endurance， urine volume， body mass， quality of life， and levels of inflammatory cytokines were compared between the two groups before and after treatment. ResultBefore treatment， the two groups of patients showed no significant differences in terms of 24 h urine volume， body mass， 6 minute walk test （6MWT）， Minnesota Living with Heart Failure Questionnaire （MLHFQ） score， N-terminal pro-B-type natriuretic peptide （NT-proBNP） level， left ventricular ejection fraction （LVEF）， stroke volume （SV）， and serum levels of interleukin-6 （IL-6）， interleukin-4 （IL-4）， and tumor necrosis factor-alpha （TNF-α）. After treatment， the observation group outperformed the control group in terms of the response rates regarding traditional Chinese medicine symptom scores and New York Heart Association （NYHA） grading of cardiac function （P<0.05）. After treatment， the body mass， MLHFQ score， and IL-6， TNF-α， and NT-proBNP levels decreased in both groups （P<0.05， P<0.01）， and the observation group showed more significant decreases than the control group （P<0.05， P<0.01）. Both groups showed increases in 24-h urine volume， 6MWT， LVEF， SV， and IL-4 after treatment （P<0.05， P<0.01）， and the observation group showed more significant increases than the control group （P<0.05， P<0.01）. ConclusionThe combination of Bushen Huoxue prescription with standardized treatment is effective in ameliorating the clinical symptoms of the patients with chronic heart failure resistant to diuretics. Moreover， it alleviates diuretic resistance and improves the cardiac function without causing obvious adverse reactions.
