Traditional Chinese Medicine Treats Heart Failure by Regulating Autophagy via AMPK/mTOR Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20240924
- VernacularTitle:基于AMPK/mTOR信号通路介导自噬探讨中医药治疗心力衰竭的机制研究进展
- Author:
Wenjun MAO
1
;
Yan ZHANG
2
;
Wei ZHANG
3
;
Yaqin WANG
1
;
Ziyang YUAN
1
Author Information
1. Liaoning University of Traditional Chinese Medicine （TCM）， Shenyang 110847， China
2. The Affiliated Hospital of Liaoning University of TCM， Shenyang 110032， China
3. Shenyang Pharmaceutical University， Shenyang 110016， China
- Publication Type:Journal Article
- Keywords:
adenosine monophosphate-activated protein kinase （AMPK）/mammalian target of rapamycin （mTOR） signaling pathway;
autophagy;
traditional Chinese medicine;
heart failure;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(21):112-122
- CountryChina
- Language:Chinese
-
Abstract:
Heart failure （HF） is a group of syndromes caused by cardiac dysfunction with impaired ventricular pumping， seriously affecting patients' health and quality of life. The pathogenesis of HF is complex， including myocardial contractility decline， myocardial fibrosis， and ventricular remodeling， and it is related to neuroendocrine regulation， inflammation， and cardiomyocyte autophagy. Autophagy is a key regulatory mechanism by which cells degrade themselves to maintain body homeostasis. In the process of HF， moderate autophagy can remove aging and damaged cardiomyocytes and maintain the balance of myocardial energy metabolism， while abnormal autophagy may lead to functional decline and pathological changes of cardiomyocytes. The adenosine monophosphate-activated protein kinase （AMPK）/mammalian target of rapamycin （mTOR） signaling pathway is one of the classical pathways regulating autophagy. This pathway can mediate the autophagy of cardiomyocytes and play a role in protecting the cardiac function and delaying HF progression. Traditional Chinese medicine （TCM） with a long history has a unique theoretical system and shows satisfactory therapeutic effects and wide application prospects amid the integration with modern medicine. The clinical practice of TCM has accumulated rich experience in the treatment of cardiovascular diseases. A large number of studies have shown that the active components and compound prescriptions of TCM and Chinese patent medicines can mediate autophagy by regulating the AMPK/mTOR signaling pathway to treat HF. This article explains the role of AMPK/mTOR signaling pathway-mediated autophagy in the treatment of HF， introduces the understanding of autophagy， AMPK/mTOR signaling pathway， and HF based on TCM theories， and reviews the research progress in the regulation of autophagy by TCM in the treatment of HF via the AMPK/mTOR pathway. This review is expected to tap the potential of TCM in the treatment of cardiovascular diseases， provide theoretical support for subsequent experimental studies， and demonstrate the advantages of TCM in clinical practice to achieve more accurate treatment.
