Clinical research progress of traditional Chinese medicine in the treatment of GERD with anxiety and depression by regulating brain-gut axis
- VernacularTitle:中医药调控脑-肠轴治疗GERD伴焦虑抑郁症的临床研究进展
- Author:
Yuqing WANG
1
;
Zuomei LUO
1
;
Nan CHEN
1
;
Bingjie HAN
1
;
Liqun LI
2
;
Lijian LIU
2
;
Guangwen CHEN
2
;
Chengning YANG
2
Author Information
1. Graduate School of Guangxi University of Chinese Medicine，Nanning 530001，China
2. Dept. of Spleen and Stomach Diseases，the First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530001，China
- Publication Type:Journal Article
- Keywords:
gastroesophageal reflux disease;
anxiety;
depression;
brain-gut axis;
traditional Chinese medicine;
integration of
- From:
China Pharmacy
2024;35(18):2315-2320
- CountryChina
- Language:Chinese
-
Abstract:
Gastroesophageal reflux disease （GERD） is a gastrointestinal motility disorder characterized by the reflux of gastric contents into the esophagus， leading to symptoms such as acid reflux and heartburn. The incidence of GERD is closely associated with psychological disorders， including anxiety and depression. The brain-gut axis， serving as a mediator of the bidirectional connection between the brain and the gastrointestinal tract， plays a crucial role in the occurrence and development of GERD with anxiety and depression. Various therapeutic approaches， including compound Chinese medicine internal therapy （such as Pingchong jiangni decoction， Tiaozhong huashi decoction， etc.）， combination therapy of internal and external Chinese medicine （such as Lianzhi xiere decoction combined with acupoint application， acupuncture at the back segment of governor vessel plus Chinese medication of soothing the liver and gallbladder， etc.）， and combination therapy of internal Chinese and western medicine （including Jianpi shugan decoction combined with rabeprazole， rabeprazole combined with Jianzhong jiangni decoction， etc.）， have been shown to regulate brain-gut peptides， intestinal flora， inflammatory factors and gastrointestinal hormones， thereby effectively alleviating GERD symptoms， anxiety and depression， and enhancing patients’ quality of life.
