The optimal scaffold for silk sericin‑based bone graft: collagen versus gelatin
10.1186/s40902-022-00368-0
- Author:
Ji Hae LEE
1
;
HaeYong KWEON
;
Ji‑Hyeon OH
;
Seong‑Gon KIM
Author Information
1. Sericultural and Apicultural Division, National Institute of Agricultural Science, RDA, Wanju 55365, Republic of Korea
- Publication Type:RESEARCH
- From:Maxillofacial Plastic and Reconstructive Surgery
2023;45(1):2-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Silk sericin is an active ingredient in bone grafts. However, the optimal scaffold for silk sericin has yet to be identified.Method A critical-sized bone defect model in rat calvaria was used to evaluate bone regeneration. Silk sericin from Yeonnokjam, Bombyx mori, was incorporated into gelatin (group G, n = 6) and collagen (group C, n = 6). Bone regen‑eration was evaluated using micro-computed tomography (mCT) and histology.
Results:Group C showed a larger bone volume than group G in the mCT analysis (P = 0.001). Histological analysis showed a larger area of bony defects in group G than in group C. The bone regeneration area in group C was signifi‑cantly larger than that in group G (P = 0.003).
Conclusion:Compared with gelatin, collagen shows better bone regeneration in silk sericin-based bone grafts.
