Lattice radiotherapy in inflammatory breast cancer: report of a first case treated with curative aim

Author: Silvana PARISI ¹ ; Miriam SCIACCA ; Paola CRITELLI ; Giacomo FERRANTELLI ; Federico CHILLARI ; Valeria VENUTI ; Claudio NAPOLI ; Issa SHTEIWI ; Carmelo SIRAGUSA ; Anna BROGNA ; Antonio PONTORIERO ; Gianluca FERINI ; Anna SANTACATERINA ; Stefano PERGOLIZZI
Author Information

1. Radiotherapy Unit, Department of Biomedical, Dental Science and Morphological and Functional Images, University of Messina, Messina, Italy
Publication Type:Case Report
From:Radiation Oncology Journal 2024;42(2):160-165
CountryRepublic of Korea
Language:English
Abstract: Inflammatory breast cancer (IBC) is a rare, aggressive form of breast cancer characterized by poor prognosis. The treatment requires a multidisciplinary approach, with neoadjuvant chemotherapy, surgery, and radiation therapy (RT). Particularly, high doses of conventional RT have been historically delivered in the adjuvant setting after chemotherapy and mastectomy or as radical treatment in patients ineligible for surgery. Here, we report the case of a 49-year-old woman patient with IBC unsuitable for surgery and treated with a combination of lattice RT and fractionated external beam RT concurrent with trastuzumab, with a curative aim. One year after RT, the patient showed a complete response and tolerable toxicities. This is the first reported case of a not-operable IBC patient treated with this particular kind of RT.