Deep Sedation in Traumatic Brain Injury Patients
10.13004/kjnt.2023.19.e19
- Author:
Yoon-Hee CHOO
1
;
Youngbeom SEO
;
Hyuk-Jin OH
Author Information
1. Department of Neurosurgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
- Publication Type:Review Article
- From:Korean Journal of Neurotrauma
2023;19(2):185-194
- CountryRepublic of Korea
- Language:English
-
Abstract:
Traumatic brain injury (TBI) is one of the leading causes of mortality and disability in adults. In cases of severe TBI, preventing secondary brain injury by managing intracranial hypertension during the acute phase is a critical treatment challenge. Among surgical and medical interventions to control intracranial pressure (ICP), deep sedation can provide comfort to patients and directly control ICP by regulating cerebral metabolism. However, insufficient sedation does not achieve the intended treatment goals, and excessive sedation can lead to fatal sedative-related complications. Therefore, it is important to continuously monitor and titrate sedatives by measuring the appropriate depth of sedation. In this review, we discuss the effectiveness of deep sedation, techniques to monitor the depth of sedation, and the clinical use of recommended sedatives, barbiturates, and propofol in TBI.
