Changes in proteinuria and the associated risks of ischemic heart disease, acute myocardial infarction,and angina pectoris in Korean population
- Author:
Sung Keun PARK
1
;
Ju Young JUNG
;
Min-Ho KIM
;
Chang-Mo OH
;
Eunhee HA
;
Eun Hye YANG
;
Hyo Choon LEE
;
Soonsu SHIN
;
Woo Yeon HWANG
;
Sangho LEE
;
So Youn SHIN
;
Jae-Hong RYOO
Author Information
- Publication Type:Original Article
- From:Epidemiology and Health 2023;45(1):e2023088-
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES:Proteinuria is widely used to predict cardiovascular risk. However, there is insufficient evidence to predict how changes in proteinuria may affect the incidence of cardiovascular disease.
METHODS:The study included 265,236 Korean adults who underwent health checkups in 2003-2004 and 2007-2008. They were categorized into 4 groups based on changes in proteinuria (negative: negative → negative; resolved: proteinuria ≥1+ → negative; incident: negative → proteinuria ≥1+; persistent: proteinuria ≥1+ → proteinuria ≥1+). We conducted 6 years of follow-up to identify the risks of developing ischemic heart disease (IHD), acute myocardial infarction (AMI), and angina pectoris according to changes in proteinuria. A multivariate Cox proportional-hazards model was used to calculate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for incident IHD, AMI, and angina pectoris.
RESULTS:The IHD risk (expressed as HR [95% CI]) was the highest for persistent proteinuria, followed in descending order by incident and resolved proteinuria, compared with negative proteinuria (negative: reference, resolved: 1.211 [95% CI, 1.104 to 1.329], incident: 1.288 [95% CI, 1.184 to 1.400], and persistent: 1.578 [95% CI, 1.324 to 1.881]). The same pattern was associated with AMI (negative: reference, resolved: 1.401 [95% CI, 1.048 to 1.872], incident: 1.606 [95% CI, 1.268 to 2.035], and persistent: 2.069 [95% CI, 1.281 to 3.342]) and angina pectoris (negative: reference, resolved: 1.184 [95% CI, 1.065 to 1.316], incident: 1.275 [95% CI, 1.160 to 1.401], and persistent: 1.554 [95% CI, 1.272 to 1.899]).
CONCLUSIONS:Experiencing proteinuria increased the risks of IHD, AMI, and angina pectoris even after proteinuria resolved.
