Neuromuscular Block by Vecuronium and its Reversal with Pyridostigmine in Rabbits.
10.4097/kjae.1988.21.2.307
- Author:
Kyoung Hun KIM
1
;
Dong Ho LEE
;
Kyo Sang KIM
;
Jung Kook SUH
;
Hee Koo YOO
;
Ik Sang SEUNG
;
Se Ung CHON
Author Information
1. Department of Anesthesiology, Hanyang University Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Muscle relaxant;
vecuronium;
Anticholinesterase;
pyridostigmine
- MeSH:
Body Fluids;
Cholinesterase Inhibitors;
Edrophonium;
Humans;
Neostigmine;
Neuromuscular Blockade*;
Pharmacokinetics;
Pyridostigmine Bromide*;
Rabbits*;
Vecuronium Bromide*
- From:Korean Journal of Anesthesiology
1988;21(2):307-312
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Despite the fact that the anticholinesterases, mainly neostigmine, has been used for many years to antagonize a nondepolarizing neuromuscular blockade, until recently nothing was known about their pharmacokinetics and dynamics in anesthetized patients. This deficiency was largely due to lack of a suitable analytic technique to measure the concentration of these drugs in body fluids, most importantly serum. Recently it was developed a method by which the serum concentrations of neostigmine, pyridostigmine, edrophonium and their metabolities can be measured. Recently,k pyridostigmine and edrophonium have gained popularity to use for reversing a nondepolarizing muscle relaxants. We have studied newly introduced vecuronium effects and its reversal with pyridostigmine. The results were as follows: 1) Spontaneous recovery index by vecuronium 0.1mg/kg was 620.8 sec. 2) Recovery index by the pyridostigmine 160ug/kg reversal was significantly shortened as 134.0sec in vecuronium 0.1mg/kg block. 3) Tetanic stimulation (100Hz, 5sec) was sustained after 75% recovery of twitch height by pyridostigmine 160ug/kg reversal.
